O'Neill was born in Minooka, Pennsylvania, to Irish immigrants from Maum, County Galway, Michael "Squire" O'Neill and the former Mary Joyce. He was one of four brothers who escaped a life in the coal mines by playing in the major leagues. Other notable members of the O'Neill family were Jack, a catcher in the National League ; Mike, a right-handed pitcher in the NL ; and Jim, an infielder with the American League Washington Senators. Baseball historian William C. Kashatus noted that Michael and Jack "would become the first brother battery in major league history". The O'Neill brothers "were known to exchange their signals in Gaelic in order to fool the opposing coaches". Later, two of Steve O'Neill's daughters married professional baseball players, one of whom was Skeeter Webb, who played under O'Neill in the minor leagues in 1939 and again from 1945–47, when O'Neill piloted the Tigers. Steve had by far the most successful playing career of the O'Neill brothers, serving as a catcher for 17 years in the American League. He played with the Cleveland Indians, Boston Red Sox, New York Yankees, and St. Louis Browns. His playing career curtailed by an injury sustained in a car accident, O'Neill compiled a batting average of.263 with 13 home runs and 534 RBI in 1,590 games, and, in his only World Series appearance in 1920, hit.333 in seven games as the backstop for the world champion Indians. When his playing career ended, O'Neill turned to managing in the minors and gained a reputation for cultivating talented young players, some of whom went on to become Hall of Famers. He managed the Toronto Maple Leafs , Toledo Mud Hens, Buffalo Bisons and Beaumont Exporters. As a big league manager with four teams—the Indians, Tigers, Red Sox and Philadelphia Phillies —O'Neill never had a losing record. His Tigers won the 1945 World Series and O'Neill was known for turning around under-performing teams, often in mid-season. His career winning percentage over 14 seasons was a stalwart.559. He also served as a coach for Cleveland, Detroit and Boston. Legendary players who benefited from O'Neill's guidance included Lou Boudreau, Bob Feller, Hal Newhouser, and Robin Roberts. O'Neill was inducted into the International League Hall of Fame. He was also an inaugural member of the Cleveland Indians Hall of Fame. O'Neill died at age 70 in Cleveland, Ohio, after suffering a heart attack, and is interred in St. Joseph's Cemetery, Minooka.