Swedo received a BA degree from Augustana College in 1977, and an MD from Southern Illinois University School of Medicine in 1980. Her internship and residency in pediatrics were conducted at the Children’s Memorial Hospital of the McGaw Medical Center of Northwestern University. Following completion of her residency, Swedo served as Chief of the Division of Adolescent Medicine at the Northwestern until 1986, when she joined Judith L. Rapoport's laboratory as a senior staff fellow in the Child Psychiatry Branch of the National Institute of Mental Health. There, she conducted research on pharmacological treatments for childhood obsessive-compulsive disorder, and was granted tenure in 1992. In 1994, she was named Head of the Section on Behavioral Pediatrics, and from 1995 to 1998 also served as the Acting Scientific Director for NIMH. In 1998, she became Chief of the Pediatrics and Developmental Neuropsychiatry Branch at NIMH. At PDN, Swedo conducts research on the causes and treatment of pediatric neuropsychiatric disorders, including OCD, anxiety disorders, and autistic spectrum disorders. Swedo is lead author on a 1994 paper in the journal Pediatrics proposing a link between Group A streptococcal infection in children and some rapid-onset cases of OCD or tic disorders such as Tourette syndrome. This proposed subtype of repetitive behavior disorder is now referred to as PANDAS. Swedo is a member of the DSM-V task force, which expects to publish an updated version of the Diagnostic and Statistical Manual of Mental Disorders in 2012. Swedo has won several awards, including the American Academy of Child and Adolescent Psychiatry Award for Scientific Achievement and the American College of Neuropsychopharmacology International Award for Clinical Research. She has written It's Not All In Your Head: The Real Causes and Newest Solutions to Women's Most Common Health Problem, and co-authored with Henrietta LeonardIs it "Just a Phase"?: How to Tell Common Childhood Phases from More Serious Problems.
PANDAS
In 1994, Swedo was lead author on a paper describing Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections. The proposed mechanism, similar to that of rheumatic fever, is one of an inappropriate autoimmune response in the brain, leading to repetitive behaviors. The proportion of cases of these neuropsychiatric disorders, if any, following this mechanism is not clear.
Autism study
In September 2006, Swedo launched a study of the widespread but unproven use of chelation therapy, which is based on the hypothesis that the mercury-containing vaccine preservative thiomersal is linked with autism. The trial was to compare the chelator DMSA with placebo, with the social and language skills of the subjects being evaluated after twelve weeks. The trial was halted in February 2007 due to ethical concerns about safety following new evidence of risks of permanent cognitive and emotional problems in otherwise-healthy rodents that were given DMSA.
