In Rhodesia his school expelled him. He moved to Czechoslovakia to study on an NDP scholarship with help from Rupiah Banda, the International Secretary of the ZambiaStudents Union. Banda established contact between Sekeramayi and the NIB. In June 1964 he moved from Czechoslovakia to Lund, Sweden, on an NIB scholarship. He studied genetics at the University of Lund, became ZANU's representative in Sweden, and then attended medical school. In Lund he studied with Alexander Chikwanda of the United National Independence Party of Zambia. In 1969 Sekeramayi requested assistance from SIDA in his function as Secretary-General of the Zimbabwe Students' Union in Europe. He coordinated Herbert Chitepo and Richard Grove's visits to Sweden. In 1976 he moved to Mozambique. In the 1980s he participated in the Gukurahundi massacres. In 2001 Defense MinisterMoven Mahachi died in a car crash and Sekeramayi became the new Defense Minister. In 2005 William Mervin Gumede mentioned Sekeramayi as one of several leading politicians who may succeed Mugabe as President of Zimbabwe because of their support among the military. He is considered a close ally of Emmerson Mnangagwa, formerly the Speaker of Parliament, and Joyce Mujuru. Sekeramayi won the House of Assembly seat from Marondera East constituency, in Mashonaland East Province, as the ZANU-PF candidate in the March 2005 parliamentary election. According to official results he defeated Movement for Democratic Change candidate Iain Kay with 19,912 votes against Kay's 10,066 votes; this victory was questioned on the grounds that the total number of votes was said to exceed voter turnout. In the ZANU-PF primaries for the March 2008 parliamentary election, Sekeramayi again sought the party's nomination as its candidate for the House of Assembly seat from Marondera East, but was defeated. He was instead nominated as ZANU-PF's candidate for the Senate from Marondera-Hwedza in Mashonaland East. Sekeramayi won this seat according to official results, receiving 24,571 votes against 17,370 for Jane Chifamba of the MDC-Tsvangirai faction and 6,994 for Molai Penelope of the MDC-Mutambara faction. On 7 January 2009, The Herald reported that Sekeramayi had been appointed as Acting Minister of Mines and Mining Development following the dismissal of Amos Midzi, who failed to win a seat in the 2008 election. When the national unity government was sworn in on 13 February 2009, Sekeramayi became Minister of State Security. He was at this point in time seen as a likely Mugabe successor who is less controversial. Following the dissolution of the Cabinet of Zimbabwe in 2017, it was announced that Mnangagwa allowed only Patrick Chinamasa and Simbarashe Mumbengegwi to remain as acting ministers of Finance and Foreign Affairs respectively until the appointment of a new cabinet.