Following the launch of ABS-CBN TV-10 Batangas as an originating station in 2008 was the launch of the regional edition of News Patrol with ABS-CBN Naga's Sarita Kare as its anchor together with Joan Panopio and Tina Ganzon as reporters. The province-wide news advisory then aired several times in weekdays and weeknights, while the national edition airs on weekends.
Kare era
TV Patrol Southern Tagalog began on February 9, 2009, which led to the newscast to expand its coverage to the entire Southern Tagalog regions. On May of that year, the newscast covered events on Pahiyas Festival after ABS-CBN Batangas took over the coverage from ABS-CBN Naga. On August 31, the newscast has been relaunched with Alex Santos as its guest anchor. On the second half of 2010, Edison Reyes joins Kare as her co-anchor, after few months, Reyes left and moved to TV5 (now 5 as its national TV and radio reporter. Kare left the program in 2013 and Reyes would later resigned to another network as he ventured into politics, and elected as councilor in Majayjay, Laguna on the 2016 elections.
Hernandez and Parole eras
TV Patrol Southern Tagalog was later anchored by experienced Batangas Citynews anchor Paul Hernandez and Joan Panopio respectively replacing Kare. The program is backed by a formidable team of ABS-CBN reporters. Panopio left the program and returned to field reporting leaving Hernandez as the sole anchor. In 2014, TV Patrol Southern Tagalog moved its studio from the Philam Life Building to its new home at Seasons. Paul Hernandez was then joined by Aya Parole in 2015. Hernandez later on left the newscast, leaving Parole as its main anchor.
Balita era
Senior correspondent Val Balita replaced Aya Parole after the latter left the newscast. The program also introduce new reporters Fay Virrey, Kevin Dinglasan and Mariz Laksamana. One of its original correspondent Ernie Manio joined the Manila news team, as well. On January 9, 2017, TV Patrol Southern Tagalog updated its opening billboard, title card and graphics similar to the main national newscast which took effect 6 months earlier opposite TV Patrol Southern Mindanao.
Magistrado era
Former ABS-CBN Naga correspondent Jonathan Magistrado replaced Balita as the newscast's main anchor in June 2019. Fellow Naga City-based Rona Nunez and is also reassigned to the bureau, displacing its in-house personnel. However, by August 2019, the station restarted employing Batangas-based personnel as additional field reporters along with former TV Patrol Ilocos reporter Kim Lorenzo. On May 5, 2020, the newscast aired its final broadcast on television as the National Telecommunications Commission ordered to shutdown ABS-CBN, including its AM and FM radio stations and regional stations nationwide. It returned on May 8, 2020 but pre-recorded on their official Facebook page, YouTube channel of ABS-CBN Regional, iWant and replay's at 8:45 pm on ANC.