Tantra is the story of a family which has fallen prey to the clutches of an evil incantation. The Khannas are an affluent family who move into their dream home 'Jalsa' but become unfortunate victims of the gruesome practice of tantra. The antagonist is the House itself whose haunting effects make the place unliveable and a nightmare for its inhabitants. Niyati, the beautiful and brave daughter of the Khanna family emerges as the one who can fight against the evil and protect her family from the witchcraft. Niyati and her family move in to 'Jalsa' and on their first night in the house, Niyati's brother Nirvaan is attacked by the tantra and almost killed, only to be saved by Niyati. Niyati notices that the wires which were choking Nirvaan were moving on their own leading to her suspision that something is wrong. Her mother, Sumati, refuses to believe her and instead blames her for not paying attention to Nirvaan. Soon, an old lady staying in the house opposite to Jalsa, is killed as she knew about the black magic inhabiting the house. Niyati and her childhood friend, Akshat, investigate and begin to suspect Kanchan, a waitress they had seen at a party. Kanchan recalls having seen Saudamini at the same party. When she tries testifying against Saudamini, she and Akshat are abducted by Saudamini and saved in the nick of time by Niyati. The goons who kidnapped them mysteriously commit suicide without revealing who was giving them orders. Niyati witnesses a house maid being dragged by supernatural forces into a wall. Terrified by the sight, Niyati tries to convince her parents about the mysterious occurrences in the house. Nirvaan begins dating a mysterious girl named Nisha who is later revealed to be Saudamini's daughter. Saudamini casts a spell upon the family members except Niyati which makes them believe that Nirvaan and Nisha are getting married in a couple of days. In a baffling plot twist, it is revealed that Kanchan is actually working with Saudamini and helping her in her evil plans and that Nisha is posing as Saudamini's daughter because her parents are being held captive by Saudamini. During a party at Jalsa, Nirvaan is put under a spell by Saudamini and Kanchan which causes him to misbehave with Nisha following which she reveals to Prithvi and the family that Nirvaan tried to harass her. While Prithvi questions Nirvaan's actions, Niyati supports her brother and lashes out at Nisha and Saudamini accusing Nisha of falsely framing Nirvaan. Nisha breaks up with Nirvaan on Saudamini's orders. Nirvaan, who is still under the spell, behaves violently, blames Niyati for the break-up and commits suicide under the spell's influence. Niyati, who was following Saudamini and Nisha to uncover their secret, loses track of them in a forest and comes across a priest who tells her that her house is controlled by evil forces. She rushes home to inform her parents only to find Nirvaan has committed suicide. She is grief-stricken and tries to convince the devastated family of the rituals going on in her house only to be rejected and slapped by an inconsolable Sumati who blames Niyati and reveals that she is adopted. It is later revealed that Niyati is Kanchan's sister and Saudamini's niece. Saudamini's sister's husband had committed suicide due to Prithvi and Saudamini wants to avenge her sister becoming a widow by ruining the Khannas. Niyati chooses to support Prithvi and along with Akshat, who she later marries, they vow to stand up against the evil forces and protect them from the looming dangers of black magic. Kanchan also capture akshat soul in order to ruin niyati married life. But at the end, niyati saves akshat by releasing his soul fron soul world. Kanchan also control niyati family against her by performing black magic on them with the help of an actress in the form of sage. But she fails and died at the end. Niyati, akshat and her family lives happily ever after. The show ends.