Tax is produced by members of the retroviral family primate T-lymphotropic virus, which are classified as Deltaretroviruses. This includes Human T-lymphotrophic viruses, bovine leukaemia virus and simian T-lymphotropic viruses. The tax protein produced from HTLV-1 and HTLV-2 have been most extensively studied. The gene for Tax is found within the pX region between the env gene and one of the long terminal repeats of the viral genome; which is where the name Tax comes from. Tax acts as a transactivator, causing the transcription of viral proteins in the long terminal repeat that are essential for replication.
Role in disease
causes an aggressive form of leukaemia: adult T cell leukaemia, and Tax has largely been implicated in the oncogenic potential of this virus. In addition to Tax's ability to promote the transcription of viral proteins in the nucleus, it also regulates many human genes. It does this by modulating the activity of several signaling pathways such as: CREB/ATF, NF-κB, AP-1 and SRF. Tax modulates cellular processes by protein-protein interaction, transcriptional activation and transcriptional repression. Cellular processes that Tax dysregulates to produce cancerous cells include the cell cycle and the maintenance of genomic integrity. The cell cycle has four stages and Tax is known to accelerate the transition between G1 and S phase. Two DNA repair pathways are affected by Tax, leading to mutations in DNA; a classical hallmark of cancer. Tax also causes aneuploidy, which is a possible cause of transformation. Many proteins are involved in these processes, including cyclins and cell cycle checkpoint proteins. Interesting, HTLV-1 Tax viral gene is known to dampen innate antiviral signaling pathways to avoid host detection and elimination, through SOCS1 and Aryl Hydrocarbon Receptor Interacting Protein. Although Tax from HTLV-1 and HTLV-2 can cause cells to become cancerous experimentally, Tax produced by HTLV-2 is less oncogenic than that from HTLV-1 and therefore is thought to be the reason that HTLV-2 is not associated with ATL.
