SR 57 starts in Memphis by going south on Trezevant Street from SR 14. Trezevant St. turns into East Parkway and follows US 70/US 79/US 64 and SR 277. They have an intersection with Sam Cooper Boulevard before SR 57 turns east and follows US 72 along Poplar Avenue, where it starts to follow the Norfolk Southern Railway to the north. Poplar Avenue has an interchange with I-240 in East Memphis and soon enters Germantown, where it is briefly overlapped with SR 177. As the road enters Collierville, it becomes known as West Poplar Avenue. SR 57 meets Byhalia Road as a crossroads. Just east of that intersection US 72 diverges from SR 57 by going southeast into Mississippi, via unsigned SR 86, while SR 57 continues east along West Poplar Ave. SR 57 becomes a two-lane road but remains at a speed until it exits Collierville. East of the Collierville town square, it becomes East Poplar Avenue and SR 205 has its southern terminus at SR 57. Poplar Avenue is a major thoroughfare through Shelby County and has much commercial development along its route. In the city of Memphis, the road is locally known for its narrow lanes of traffic and hazardous storm grates along its edges. The many freight trains that run along the side of it cause several traffic delays throughout the day.
Fayette County
When SR 57 enters Fayette County, the speed limit increases to and except for when the road passes through a town, it remains at this speed until it ends in Mississippi. Just outside Collierville, SR 57 has an interchange with I-269. In the city ofPiperton, SR 57 intersects with SR 196 and crosses over the Norfolk Southern Railway. A few miles down the road, it passes through Rossville and is the southern terminus for SR 194. SR 57 passes over the Wolf River and passes through Moscow. The southern terminus of SR 76 occurs in Moscow. Several miles down the road from here, SR 57 passes through LaGrange. Motorists can view several of the town's historic buildings from the road. East of LaGrange, SR 57 turns left along SR 18, passes over the Norfolk Southern Railway again, and then continues east.
Former Alignment
A former alignment of SR 57 exists for 1.2 miles in Piperton. The former route exits SR 57 heading south as Commerce Road, and after approximately 450 feet turns eastward into West Old State Line Road. Old State Line Road then briefly turns into SR 196 before becoming East Old State Line Road. After half a mile, East Old State Line Road turns slightly left before reentering SR 57.
After splitting from SR 18, SR 57 enters Hardeman County and also enters Grand Junction. It is home to the National Bird Dog Museum, which is visible from the road. SR 57 crosses over the Mississippi Central Railroad and junctions with SR 368. Several miles east is the town of Saulsbury. East of Saulsbury, SR 57 passes over the Norfolk Southern Railway for a third time, and continues east to Middleton. Here, it intersects with SR 125 and crosses the Mississippi Tennessee Railroad. East of Middleton, SR 57 goes through the town of Pocahontas, where it passes over the Norfolk Southern Railway for the fourth and final time. The railroad continues southeast into Mississippi while SR 57 continues east. It also passes over the Hatchie River around Pocahontas.
SR 57 enters McNairy County and passes north of Big Hill Pond State Park. SR 57 passes through Ramer, where it is the northern terminus of SR 234. It also crosses over the West Tennessee Railroad. SR 57 continues east and crosses US 45 near the town of Eastview. after crossing US 45, SR 57 goes north of the town of Michie and intersects with SR 224. East of Michie, the road junctions with SR 22, which is the most direct route to Shiloh National Military Park.
SR 57 passes into Hardin County and intersects with SR 142 west of the town of Counce. When SR 57 enters the town of Counce, it crosses a railroad spur of the Kansas City Southern Railway. East of the town, the road intersects with SR 128 in Pickwick Village. SR 128 goes north over Pickwick Dam, and SR 57 turns right and heads south toward Pickwick Landing State Park. SR 57 continues south along Pickwick Lake for approximately until it crosses into Mississippi and becomes Mississippi Highway 25.
