On August 22, 2009, Weber tossed the Erie SeaWolves' first no-hitter in almost 14 years. Weber faced two batters over the minimum, struck out a career-high 10, and threw only 88 pitches en route to the historic achievement. Weber was called up by the Detroit Tigers on April 21, 2012, and made his major league debut the next day against the Texas Rangers. The Rangers won 3-2 in 11 innings. He was optioned back to the minor leagues by Detroit on April 26, 2012, after making two appearances.
San Diego Padres
In August 2012, Weber was signed by the San Diego Padres. The Padres designated Weber for assignment on May 17, 2013.
On May 19, the Toronto Blue Jays claimed Weber off waivers, and optioned him to the Triple-A Buffalo Bisons. Weber was recalled by the Blue Jays on May 25. Weber was optioned back to the Buffalo Bisons by the Blue Jays on May 28. He was recalled on June 9, and then returned to Buffalo after that day's game. On August 13, Weber was recalled again by the Blue Jays to replace Josh Johnson, who was placed on the 15-day disabled list. Weber was optioned back to Buffalo on August 19, but was expected to be activated as the 26th player for the doubleheader against the New York Yankees on August 20.
On January 20, 2015, the Detroit Tigers signed Weber to a minor-league contract. During the 2015 season, Weber started 27 games for the Toledo Mud Hens and had a 6–10 record with a 4.19 ERA and 105 strikeouts. On December 11, 2015, Weber signed a minor-league contract with the Detroit Tigers. Weber spent the 2016 season shuffling between the Toledo Mud Hens and the Erie SeaWolves, the triple-A and double-A minor league affiliates of the Detroit Tigers, respectively. On January 10, 2017, Weber signed a minor-league contract with the Tigers. He was released on March 25, 2017.
On May 12, 2017, Weber signed a minor league deal with the Colorado Rockies. He was released on November 1, 2017.
Personal info
Thad Weber has a degree in Biological Sciences, graduating on May 10, 2008. He missed the UL-Lafayette series, as his wife Megan gave birth to their daughter, Babe, in 2008. He also has 2 sons, Gehrig, born in 2010, Teddy, born in 2013, and a daughter Wynn, born in 2019.