The plot involved a little girl named Marcella whose Raggedy Ann and Andy dolls would come to life when no humans were present in her bedroom. Then they would be whisked off to a parallel world to save its inhabitants from the villain, an evil but inept sorcerer known as Cracklin. Also aiding Ann and Andy were two of Marcella's other stuffed animals, a panda with a faux-British accent known as Grouchy Bear and a stuffed rabbit known as Sunny Bunny. Sometimes they would be joined by more modern toys such as robots or toy soldiers. Often the plot involved the toys helping children in such places as Ancient Egypt or a Native American tribe. As the cartoon was meant for younger audiences it was unlike most other cartoons of the 1980s which had "announcements", although one episode lightly touched upon the issue of poaching when Raggedy Ann, Andy and their friends had to save endangered unicorns from cattle rustlers, who sought to steal their horns for personal gain.
1. The Perriwonk Adventure: The toys track Marcella's missing locket to a village inhabited by hybrid alligator-anteater creatures called Perriwonks, who plan to sacrifice it to a dragon. 2. The Pirate Adventure: A treasure map leading to a pot of gold leads the toys to a crew of pirates who kidnap Andy. 3. The Mabbit Adventure: Cracklin steals a book of spells from the mabbits. 4. The Beastly Ghost Adventure: A ghost story told by Marcella becomes horrifyingly true when the ghost of the tale begins terrorizing the toys. 5. The Pixling Adventure: Ann and Andy must return the infant prince of the Pixleys to his home before the evil Count Gerich takes over. 6. The Ransom of Sunny Bunny Adventure: Cracklin kidnaps Sunny Bunny. 7. The Megamite Adventure: Marcella's cousin David has a robot named Megamite, who gets whisked off into the parallel world with Raggedy Ann. When Cracklin sees Megamite has the power to transform water into silver, he steals the robot and dries up the reservoir of a village of pixies, risking widespread dehydration unless Raggedy Ann can recapture Megamite. 8. The Boogeyman Adventure: Ann and Andy are sent to a wizarding world where there are reputed boogeymen. They encounter one, however he is akin to a child, saying that while he is of the same species of those monsters, he has been apprenticed under a good witch to help create good boogeymen. Cracklin kidnaps the "boogeykid" in an effort to get his own monster. 9. The Christmas Adventure 10. The Sacred Cat Adventure: Andy and Ann are sent to Egypt, where they must find a cat who belongs to a little girl who was the daughter of a recent deceased pharaoh. The cat leads them to a magic lamp which contains a genie which can get them back to Marcella's room, but it is also sought out by the princess' wicked half-sister, who seeks the lamp to usurp the princess' ascent to the throne. 11. The Little Chicken Adventure: 12. The Warrior Star Adventure 13. The Magic Wings Adventure
