The team had its origins in 1961 in the Georgia territory, when Hamilton, a five-year veteran, first began competing in Atlanta as the Assassin. Shortly afterward, Tom Renesto arrived in the area and began teaming with Hamilton to form the original Assassins team. Hamilton and Renesto became a well-traveled heel tandem through the 1960s, competing in the Mid-Atlantic territory, Georgia, Florida, California, Arizona, the Pacific Northwest, Canada, Japan and Australia among other areas, and winning championship gold along the way. They returned to Georgia in 1968 and competed in that state primarily until 1974; they spent most of their time competing in Georgia Championship Wrestling during that period, but they also went to work for an independent group called the All-South Wrestling Alliance, with Hamiilton going solo in the beginning while Renesto worked behind the scenes, then facing off in opposite corners from each other, then reuniting as babyfaces before All-South closed in late 1974. After Renesto retired from the ring, Hamilton continued The Assassins with new partners in later years, teaming up with Roger Smith and then Randy Colley, before forming the 1980s version of the masked team with Hercules Hernandez in Jim Crockett Promotions, under the management of Paul Jones, who used them as part of his feud with the popular Jimmy Valiant. That version of the team lasted until Hernandez was unmasked after losing to Valiant in a mask vs. hair match at a JCP/Maple Leaf Wrestling show in Toronto, Ontario on April 15, 1984. Barry Orton replaced Hernandez as Assassin #3 for a few months. Hamilton continued on solo after Barry left JCP, breaking his ties with Jones to turn babyface once again and feud with his former manager, which climaxed with Hamilton teaming with Buzz Tyler to beat Jones' Zambuie Express at Starrcade 1984 in Greensboro, North Carolina.
Post-wrestling
Jody Hamilton wound down his in-ring career in the Alabama territory competing under a different identity as The Flame before starting up his own promotion in Georgia, Deep South Wrestling, in 1986, which he ran for about two years before selling the promotion. He then opened up the Power Plant as a training facility for World Championship Wrestling and was last seen reprising his Assassin role as the manager of Pretty Wonderful in WCW in 1994. Hamilton reopened Deep South Wrestling in 2005 to serve as a developmental territory for World Wrestling Entertainment, but WWE severed its developmental deal with DSW on April 18, 2007, and Hamilton continued running the promotion on his own as an independent until he folded DSW shortly after its October 11, 2007 event. Tom Renesto retired from wrestling in 1974. On April 25, 2000, Renesto died at 72 years old. Randy Colley went on to form The Moondogs tag team, which competed in the then-WWF and in the Memphis area, and he was also the original Demolition Smash. He also competed in Mid-South Wrestling as the masked Nightmare, wearing the same mask he had as one of the Assassins. He retired in 1996. Roger Smith went on to fame in Memphis in the mid-1980s under the ring name Dirty Rhodes, both as a heel and a babyface. He has also since retired. Hercules Hernandez went on to fame under that name in World Class Championship Wrestling, Florida, the WWF and Japan, as the masked Mr. Wrestling III in Mid-South, and as the masked Super Invader in WCW. He died in his sleep of a heart attack in Tampa, Florida on March 6, 2004 at age 47. Jim Ross stated that the Masked Assassins "were the greatest tag team that ever saw."