The chronological placement of these adventures is unclear, but it is fair to assume that they all occur soon after the Television Movie, earlier than any other main range drama.
Fitz appeared in the Eighth Doctor Adventures novels, starting with The Taint. How he parted company with the Doctor is uncertain, as he was also in the final book of the range, The Gallifrey Chronicles.
Izzy was the first companion given to the Eighth Doctor in the Doctor Who Magazine comics. She traveled with him from End Game until Oblivion. In this audio story, they visit Stockbridge, a town which has featured in many Doctor Who Magazine comics as well as audios such as Circular Time and The Eternal Summer. Located somewhere in Gloucestershire, is also Izzy's home.
Bernice, Fitz and Izzy have all been featured previously in Big Finish's Short Tripsshort story anthologies: Fitz in ', Izzy in ' and Benny in various collections.
There have been several references in Big Finish's Eighth Doctor stories to the incident in 1816, in Lake Geneva, Switzerland, with Mary Shelley, Percy Shelley, John Polidori and Lord Byron, which resulted in Mary writing Frankenstein. The first mention is in Big Finish's very first Eighth Doctor play, Storm Warning. At its very start, the Doctor picks up the aforementioned book and reads the preface, in which she recounted her version of the incident. The Doctor implies what she had written wasn't the entire truth. This scene was repeated in its entirety in Terror Firma. In Neverland, while dazed, the Doctor blurts out warnings to Byron about meddling with terrible forces and also warns Mary that that someone or something isn't really her brother. A similar moment occurs in Zagreus, where he laments Polidori as well as Mary. In the Shada remake, the Doctor mentions meeting up with his friend Professor Chronotis at Lake Geneva with Mary and Byron. And in the last Eighth Doctor story in the main range, The Girl Who Never Was, the Doctor is very excited when he stumbles across one of Mary's books. The Doctor mentions Mary one last time before the release of Mary's Story in The Beast of Orlok. A year after its release, he recalls being at the Villa Diodati in Nevermore.
In the 1996 TV Movie, during the first moments of the Eighth Doctor's life, the 1931 film adaptation of Mary's Frankenstein was playing on a nearby television, mirroring the creature's first moments of life.
The characters Samson and Gemma, who are waiting for the Doctor in Vienna, were previously heard in Terror Firma. They are waiting for him the on the same day as Mary's Story, in June, 1816.
Mary Shelley's adventures with the Doctor continue after this, starting with The Silver Turk, in which he attempts to reunite with Samson and Gemma.
The older Doctor recalls the "years" that Mary spent journeying in the TARDIS, mentioning Cybermen, Axons and "King Herold at The Battle of Hastings". The events with the Cybermen occur in her first trip, The Silver Turk.
The older Doctor also recalls many of his former companions, including Charley Pollard, Lucie Miller, Trix MacMillan, Ssard, Compassion, Destrii, Samson and Gemma. He also mentions Alex, which may be a reference to his great-grandson, who meets in An Earthly Child.