The story is set in a portion of the galaxy populated by fifty-two different sentient species. All of these species, humanity among them, have evolved in the last five million years, and all of them have evolved in a spherical volume of space less than two hundred light-years across centred on Wolf 429. The rest of the galaxy is sterile as far as anybody can tell. Scattered irregularly across this "life-bubble" are ancient artefacts of a mysterious race called the Jokers, who apparently became extinct long before any of the current races arose. These artefacts are usually astounding feats of engineering, but leave no hints about the Jokers' physical form or day-to-day life. The only piece of translatable Joker text is a poem, which cryptically states that they have gone to their new home, which "lies at the dark side of the sun".
Plot
Dominickdaniel "Dom" Sabalos IV is the son of a prodigy of probability math, a science able to predict anything apart from anything to do with the Jokers, and the first person to have had his life fully quantified using p-math. His father, before being mysteriously assassinated, predicted that Dom too would be killed, on the day of his investiture as Chairman of his home planet of Widdershins. However, not having been told of his father's prediction, and against incalculably distant odds, Dom survives the assassination attempt. When the recording of his father's prediction is played back, a time delay added specifically for this unlikely eventuality plays a little more of the recording, in which his father makes a further prediction: that Dom will discover the Jokers' homeworld. Dom sets out, with Hrsh-Hgn, Isaac and Ig in tow, on a picaresque adventure to find the Jokers' world. He visits many corners of the "life-bubble", encountering Joker artifacts, his god-father, who is a sentient planet, and the sexless, octopoid Creapii, among many other weird and diverse aliens and planets. At the same time he finds himself surviving – at increasingly improbable odds – numerous assassination attempts by a mysterious conspiracy which has long worked to prevent anybody from locating the Jokers, assassinating anybody deemed by p-math having a chance of doing so.
Setting
The book is set in the far future. No current date is given, although the dating system is "A.S.". Widdershins is a planet orbiting the star CY Acquirii settled by a joint party of phnobes and earth-humans. The planet is mostly water and marsh. Their wealth derives from both the chance discovery of pilac, a safe death-immunity drug and googoo, a fungal copier and regenerator of human tissue. The vegetation is green.
Races
52 different sentient species exist in the novel. Chief among them are:
Earth-humans – Natives of Old Earth who have settled such diverse worlds as Third Eye and Eggplant.