The school was founded in 1989 as the Math and Science Academy. Jorge Lopez, the principal of neighboring Med High served as principal. After a year, the school's name was changed to The Science Academy of South Texas. The school colors were changed from black and gold to green and gray. Only one student received a letterman jacket with the black and gold colors. In 1992, the main building was completed and classes moved out of the portables. In 2018, construction of The Science Academy's Congressman Rubén Hinojosa Innovation Lab was completed. A supporting beam signed by the Class of 2018 can be seen near the building's mezzanine. A detailed history of The Science Academy can be found in Dr. Anna Rudolph Canter's dissertation entitled "In the Middle of an Orange Grove, Across the Street From the Tortilla Factory: The Science Academy of South Texas." Canter states: "When I began my doctoral studies at UT Austin, I studied, among other topics, minority students’ failures and successes in schools. I always remembered the students at the Science Academy of South Texas. For one course, I conducted a pilot study of the experiences of teachers at the Science Academy. As I spent time in the Valley collecting those data, I became more interested in the story behind the school. As a result, I chose to write the history of the Science Academy for my dissertation research. My goal—to write a rich, detailed, multi-voiced account of the history of the Science Academy—is represented by this dissertation."
Awards and recognition
During the 2005-06 school year, The South Texas ISD Science Academy was recognized with the Blue Ribbon SchoolAward of Excellence by the United States Department of Education, the highest award an American school can receive. In 2003, it was placed 8th on Newsweek magazine's listing of "America's Best High Schools". In 2007, U.S. News & World Report ranked The Science Academy 23rd on its list of America's Best High Schools. SciTech's sister schools South Texas Business, Education & Technology Academy, or BETA, and South Texas High School for Health Professions, or Med High, were ranked 54th and 64th respectively. In 2010, The Science Academy was ranked number twelve on Newsweek's ranking of the best high schools in the nation. It was also ranked third among other Texas high schools. In 2011, The Science Academy was ranked number twenty six on . In the 2012 issue of the U.S. News & World Report, The Science Academy ranked at number 48. Med High and BETA ranked at 104th and 245th respectively. SciTech's Advanced Placement exam passing rate was at 44%. BETA had a passing rate of 15%, and Med High had a passing rate of 27%. In the 2014 issue of the U.S. News & World Report, The Science Academy ranked at number 38 in the nation. In 2018, it was placed at 13th for Best Public High Schools in Texas and 1st in the Rio Grande Valley. In 2019, The Science Academy received the PLTW Distinguished High School award. Only 9 out of 1,624 schools in Texas received this prestigious award.
Extracurricular activities
SciTech has numerous extracurricular organizations including but not limited to: