Deeply religious April Epner, a 39-year-old Brooklynelementary school teacher, finds her life derailed by a series of events over which she has no control. Her husband Ben abruptly leaves her, her abrasive adoptive mother Trudy passes away the following day, and shortly after she is contacted by Alan, a representative of Bernice Graves, the flamboyant host of a local talk show, who introduces herself as her biological mother. Although intrigued by Bernice's claim that she was fathered by Steve McQueen, April initially resists her efforts to forge a relationship. At the same time, she finds herself attracted to Frank, the divorced father of one of her students, as the two get to know each other via lengthy telephone conversations. For their first date he escorts her to a party at Bernice's apartment. Complications arise when April discovers she is pregnant, the result of a quick and clumsy coupling with Ben on the kitchen floor just before he left her. April has longed to have a child all her life and is delighted with the news, but is confused and upset by Ben's sudden return, Frank's hasty departure, and Bernice's insistent attempts to create a bond between them. Not helping the situation is the discovery Bernice voluntarily put her up for adoption a full year after her birth and not three days later at the urging of her parents, according to the scenario she initially presented. When April miscarries, her brother Freddy tries to counsel her, but ultimately she must rely on her deep-rooted faith to deal with the betrayals she has suffered not only at the hands of those she trusted but by the God she worships as well. Eventually she offers reconciliation and forgiveness to Bernice, if Bernice will agree to "buy" a baby for her. Bernice agrees, and then Frank forgives April when she goes to him to apologize for her behavior. Later, the ending shows that April could not have the baby which Bernice paid for, so she adopted another child.
Critical response to the film was mixed, and it received a 50% rating on Rotten Tomatoes. Whereas some critics praised the film for having strong performances, others felt the film was bogged down by a weak script and technical issues. Fans of the book took issue with the substantial differences between the book and the movie. Ruthe Stein of the San Francisco Chronicle observed, "You would think that frontloading Then She Found Me with so much plot would make it play like a soap opera. But Hunt saves the movie from this fate in two ways. First she turns in a touchingly real performance, the best of her big-screen career. Forget that As Good as It Gets won her an Oscar. She's eons better and more realistic in this one... By directing Then She Found Me, Helen becomes its savior as well... Hunt knows when to rein in the Divine Miss M instead of allowing her to go into full Kabuki mode... also coaxes pitch-perfect performances from Broderick and Firth." John Anderson of The Washington Post disagreed, saying "Hunt directs a lot of this like a TV movie, and the music by the estimable David Mansfield is used to frog-march the film's emotional content, rather than letting it simply enhance the proceedings... Then She Found Me suffers from, if anything, a lack of pure confidence in the story, the actors or the audience."
The DVD was released in anamorphic widescreen format on September 2, 2008. The English audio track is in Dolby Digital 5.1 Surround Sound, and there are subtitles in English for the hearing impaired and Spanish. Bonus features include director's commentary with Helen Hunt, a behind-the-scenes look at the making of the film, cast interviews, and the original trailer.