Tofisopam Tofisopam is an anxiolytic that is marketed in several European countries . Chemically, it is a 2,3-benzodiazepine. Unlike other anxiolytic benzodiazepines however, tofisopam does not have anticonvulsant , sedative , skeletal muscle relaxant , motor skill-impairing or amnestic properties. While it may not be an anticonvulsant in and of itself, it has been shown to enhance the anticonvulsant action of classical 1,4-benzodiazepines and muscimol , but not sodium valproate , carbamazepine , phenobarbital , or phenytoin . Tofisopam is indicated for the treatment of anxiety and alcohol withdrawal , and is prescribed in a dosage of 50–300 mg per day divided into three doses. Peak plasma levels are attained two hours after an oral dose . Tofisopam is not reported as causing dependence to the same extent as other benzodiazepines, but is still recommended to be prescribed for a maximum of 12 weeks. Tofisopam is not approved for sale in the United States or Canada . However, Vela Pharmaceuticals of New Jersey is developing the D-enantiomer as a treatment for irritable bowel syndrome , with moderate efficacy demonstrated in clinical trials so far. Tofisopam is also claimed to be a PDE10A inhibitor, which may provide an alternative mechanism of action for its various therapeutic effects, and this action has been proposed to make tofisopam potentially useful as a treatment for schizophrenia . Tofisopam has been shown to act as an inhibitor of the liver enzyme CYP3A4 , and this could cause dangerous drug interactions with other medications metabolised by this enzyme, although the clinical significance of these findings remains unclear.
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