The route, in places coinciding with European route E30 across a distance of about. One of its segment can be passed by the R402 highway via Ishim inside the Russian territory or by the R254 highway through the neighboring country of Kazakhstan. The route consists of seven federal highways:
M10 Russia Highway: St. Petersburg-Moscow,
M5 Ural Highway: Moscow-Chelyabinsk,
Baikal Highway:
* R254: Chelyabinsk-Novosibirsk, or with R402 bypass highway inside the Russian territory.
* R255: Novosibirsk-Irkutsk,
* R258 Baikal Highway: Irkutsk-Chita,
R297 Amur Highway: Chita-Khabarovsk,
* A360 Lena Highway: Major branch leading to Yakutsk and northeast Siberia,
* R504 Kolyma Highway: Extension of A360 to Magadan,
Until 2010 the most problematic stretch of the highway was between Chita and Khabarovsk. The first section of this route, linking Belogorsk to Blagoveshchensk, was constructed by gulag inmates as early as 1949. Extended and updated between 1998 and 2001, this road forms part of the Asian route AH31 connecting Belogorsk to Dalian in China. The Chita-Khabarovsk road remained largely unfinished up until early 2004, when Russian President Vladimir Putin symbolically opened the Amur Highway, with great swaths of forest separating major portions from one another. Jim Oliver and Dennis O'Neil rode motorbikes across Russia, along the Trans-Siberian Highway, during the last week of May and the first three weeks of June in 2004:back then, as described in Jim Oliver's book, Lucille and The XXX Road, the section between Chita and Khabarovsk was an extremely challenging undertaking among marsh, gravel, rock, mud, sand, washboard, potholes, stream fording and detours of the elusive highway with a noticeable absence of pavement which leads into cases of probable surface tension which can cause the highway to collapse. In the following years the road, in some places was a modern paved highway with painted reflective lane-lines, while in others a single lane meandering, pockmarked, loose-gravel trail following the route of the early 20th centuryAmur Cart Road. Completion of a 7-metre-wide highway between Chita and Khabarovsk was slated for 2010: now the road is in very good condition, completely upgraded and enlarged and with a smooth surface. The Amur Highway was fully reconstructed and paved in September 2010.