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Tre recombinase
Tre
recombinase
is an
experimental
enzyme
that in
lab
tests
has
removed
DNA
inserted by
HIV
from
infected
cells
. Through
selective mutation
,
Cre recombinase
which recognizes loxP
sites
are
modified
to
identify
HIV
long terminal repeats
instead. As a result, instead of
performing
Cre-Lox recombination
, the new enzyme performs
recombination
at HIV
provirus
sites.
The
structure
of Tre in
complex
with loxLTR has been
resolved
, allowing for
analyzing
the
roles
of
individual
mutations
.