Tricyclic

History

• Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s.
• Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first typical antipsychotic.
• Imipramine, originally investigated as an antipsychotic, was discovered in the early 1950s, and was the first tricyclic antidepressant.
• Carbamazepine was discovered in 1953, and was subsequently introduced as an anticonvulsant in 1965.
• Antidepressants with a tetracyclic structure such as mianserin and maprotiline were first developed in the 1970s as tetracyclic antidepressants.
• Clozapine was introduced as the first atypical antipsychotic in the 1990s.
• Loratadine was introduced as a non-sedating second generation antihistamine in the 1990s.

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