Triphenylmethyl chloride
Triphenylmethyl chloride or trityl chloride is a white solid with the chemical formula C19H15Cl. It is an alkyl halide, sometimes used to introduce the trityl protecting group.Preparation
Triphenylmethyl chloride is commercially available. It may be prepared by the reaction of triphenylmethanol with acetyl chloride, or by the Friedel-Crafts alkylation of benzene with carbon tetrachloride to give the trityl chloride-aluminium chloride adduct, which is then hydrolyzed.Reactions
can be prepared from trityl chloride dissolved in an aprotic solvent and sodium:
Reaction with silver hexafluorophosphate gives triphenylmethyl hexafluorophosphate.
