U.S. Route 18 U.S. Route 18 is an east-west U.S. highway in the Midwestern United States . The western terminus is in Orin, Wyoming at an interchange with Interstate 25 . Its eastern terminus is in downtown Milwaukee, Wisconsin . However, US 18 runs concurrent with other U.S. routes from its western terminus to Mule Creek Junction, Wyoming . US 18 is one of the original United States highways of 1926. The US 18 designation was originally proposed for a road in Michigan from Grand Haven east to Detroit . This roadway was eventually designated as U.S. Route 16.Route description In Wyoming, US 18 runs concurrent with U.S. Route 20 from Interstate 25 to Lusk , where US 18 branches off to run concurrently with U.S. Route 85. At the unincorporated community of Mule Creek Junction in northeastern Niobrara County , US 18 leaves US 85. This ten-mile stretch from US 85 to the South Dakota border is the only segment of US 18 in Wyoming which is not co-signed with another highway.South Dakota U.S. 18 enters South Dakota west of Edgemont . It passes through Hot Springs , the Pine Ridge Indian Reservation , the Rosebud Indian Reservation , Winner , and Gregory before crossing the Missouri River near Pickstown over the Fort Randall Dam . East of the Missouri River, U.S. 18 passes through Lake Andes and Tripp before a brief concurrency with Interstate 29 near Worthing . East of I-29 , U.S. 18 passes through Canton before crossing the Big Sioux River into Iowa . The Oyate Trail is one of the names given to the section of US-18 traveling across South Dakota from I-29 east of Vermillion to Maverick Junction . Named in an attempt to encourage more tourism traffic through the lands of various AmerInd tribes in southern South Dakota, it passes through or near the Yankton Sioux Indian Reservation , the Rosebud Indian Reservation , and the Pine Ridge Indian Reservation, crossing the James River Valley, the Missouri River near Fort Randall Dam, portions of Pine Ridge, and the High Plains of South Dakota, connecting the urban areas of the middle Missouri River with the Black Hills. Portions of the road were known as the Grant Highway, Black Hills Sioux Trail , and as part of the Omaha, Rosebud and Black Hills Highway and the Custer Battlefield Trail. Towns along the road include Gregory, Winner, Olivet , Mission , Martin , Batesland , and Pine Ridge. Nearby towns and locales of interest include Rosebud, and Wounded Knee .Legal definition The South Dakota section of U.S. 18, other than the concurrency with Interstate 29, is defined at South Dakota Codified Laws § 31-4-141.Iowa U.S. 18 enters Iowa via a Big Sioux River crossing northeast of Beloit . It overlaps U.S. Route 75 for a mile near Hull and U.S. Route 59 for a mile near Sanborn . It then overlaps U.S. Route 71 through Spencer . U.S. 18 passes through Emmetsburg before intersecting U.S. Route 169 at Algona . U.S. 18 then continues east through Garner before intersecting Interstate 35 in Clear Lake . After a brief concurrency with I-35, U.S. 18 continues as a freeway bypassing Mason City to the south . At Charles City , U.S. 18 becomes a rural two-lane highway again, except for a brief concurrency with the U.S. Route 63 bypass of New Hampton . After passing through West Union , it turns northeast and joins U.S. Route 52 at Postville , then leaving 52 about east of Monona before crossing the Mississippi River into Wisconsin via the Marquette–Joliet Bridge in the city of Marquette . U.S. 18 is the designated route of the Avenue of the Saints between Clear Lake and Charles City.Wisconsin Upon entry into Wisconsin at Prairie du Chien , US 18 is the terminus for WIS 60 . The two routes are then concurrent until Bridgeport where WIS 60 splits off to the east and US 18 crosses the Wisconsin River and turns east on the other side. The route joins the US 151 expressway in Dodgeville and the two remain concurrent east to Madison . US 18 follows US 12 south of Madison and passes through or around Cambridge , Jefferson and Waukesha before terminating in Milwaukee at the junction of East Michigan Street and Lincoln Memorial Drive in downtown.Major intersections ;Wyoming ;South Dakota ;Iowa ;WisconsinSpecial routes
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