US 6N begins at an intersection with US 20 in Springfield Township, heading southeast on a four-lane divided highway. The road heads through wooded areas and reaches an interchange with I-90. From here, US 6N continues south, narrowing to a two-lane undivided road and crossing under the Canadian National's Bessemer Subdivisionrailroad line before running through forested areas with some fields and homes. The road crosses the Conneaut Creek into Conneaut Township and passes through Cherry Hill, continuing south through a mix of farmland and woodland with a few residences. The route curves southeast and intersects Pennsylvania Route 226, at which point it turns east. US 6N passes through more rural areas as it comes to a junction with the southern terminus of PA 215. The road continues east into Albion, where it becomes West State Street and passes homes. The route intersects PA 18, at which point that route turns east for a concurrency with US 6N on East State Street, passing through the commercial downtown and crossing the Bessemer Subdivision. The road passes through more residential areas, briefly crossing back into Conneaut Township before coming into Elk Creek Township and becoming an unnamed road that runs through rural areas. PA 18 splits from US 6N in Wellsburg by heading to the north, and US 6N continues east through areas of farms and woods with some homes. In the community of Lavery, the route crosses PA 98. Farther east, the road crosses into Washington Township and comes to an interchange with I-79, at which point the road is a four-lane divided highway that runs near businesses. Past this interchange, US 6N becomes a two-lane undivided road again passes through more rural surroundings before heading into more residential areas and entering Edinboro. Here, the name of the road becomes West Plum Street and it turns southeast past more homes. The route turns east into the commercial downtown, gaining a center left-turn lane, and intersects PA 99. Past this junction, the road name becomes East Plum Street and it becomes a two-lane road that passes more businesses. US 6N turns east-northeast onto Waterford Street and runs through more residential areas with Edinboro University of Pennsylvania to the south. The route continues back into Washington Township and curves northeast through agricultural areas with some residential and commercial development. The road heads east and passes through more farmland with occasional woods and homes. The route crosses into LeBoeuf Township and runs through more forested areas with some fields and residences. US 6N turns southeast and comes to an intersection with US 6 and US 19, where the route ends and the road continues east as part of US 6.
