VAV1
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.Function
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.Interactions
VAV1 has been shown to interact with:
- ARHGDIB,
- Abl gene,
- Cbl gene
- EZH2,
- Grb2,
- JAK2,
- Ku70,
- LAT,
- LCP2,
- MAPK1,
- PIK3R1,
- PLCG1,
- PRKCQ,
- S100B,
- SHB,
- SIAH2, and
- Syk.
