Victorio grew up in the Chihenne band. There is speculation that he or his band had Navajo kinship ties and was known among the Navajo as "he who checks his horse". Victorio's sister was the famous woman warrior Lozen, or the "Dextrous Horse Thief". In 1853 he was considered a chief or sub-chief by the United States Army and signed a document. In his twenties, he rode with Mangas Coloradas, leader of the Coppermine band of the Tchihendeh people and principal leader of the whole Tchihendeh Apache division, and Cuchillo Negro, leader of the Warm Springs band of the Tchihendeh people and second principal leader of the whole Tchihendeh Apache division, as well as did Nana, Delgadito, Cochise, Juh, Geronimo and other Apache leaders. Mangas Coloradas taught Victorio how to create an ambush and to wait for enemies to enter the killing zone. As was the custom, he became the leader of a large mixed band of Mimbreños and Mescaleros and fought against the United States Army. From 1870 to 1880, Victorio, chief of the Coppermine Mimbreños and principal leader of all the Tchihende, along with Loco, chief of the Warm Spring Mimbreños and second-ranking among the Tchihende, were moved to and left at least three different reservations, some more than once, despite their bands' request to live on traditional lands. Victorio, Loco and the Mimbreños were moved to San Carlos Reservation in Arizona Territory in 1877. Victorio and his followers left the reservation twice, seeking and temporarily obtaining hospitality in Fort Stanton Reservation among their Sierra Blanca and Sacramento Mescalero allies and relatives, before they came back to Ojo Caliente only to leave permanently in late August 1879, which started Victorio's War. Despite Nautzili's efforts, many Northern Mescalero warriors, led by Caballero and Muchacho Negro, joined him with their families, and San Juan and other Mescaleros also left their reservation; many Guadalupe and Limpia Mescalero too joined Victorio's people. Victorio was successful at raiding and evading capture by the military, and won a significant engagement at Las Animas Canyon on September 18 1879. Within a few months Victorio led an impressive series of other brilliant fights against troops of the 9th, 10th and 6th U.S. Cavalry near the Percha River , in the San Mateos Mountains and in the Cabello Mountains near the Animas Creek, and again near Aleman's Wells, San Andres Mountains west of White Sands,, then again in the San Andres Mountains routing the cavalrymen and chasing them to the Rio Grande, then at Hembrillo Canyon, San Andres Mountains. In April 1880, Victorio was credited with leading the Alma Massacre – a raid on United States settlers' homes around Alma, New Mexico. During this event, 41 settlers were killed. Victorio's warriors were finally driven off by the arrival of American soldiers from Fort Bayard. However, Victorio continued his campaign with the attack on Fort Tularosa, where his warriors had to face a detachment of the 9th Cavalry and were repulsed by the "Buffalo Soldiers" after a harsh fight. Victorio's camp near the Rio Palomas, in the Black Range, was surprised and attacked on May 23–25, 1880, but the Mimbreños and Mescaleros succeeded in repulsing the soldiers. After the Rio Palomas battle, Victorio went on some raids to Mexico repeatedly fording the Rio Grande, after having been intercepted and beaten off, with a 60 warriors' party, at Quitman Canyon. Chased by more than 4.000 armed men Victorio fooled all of them during more than one month. On August 9, 1880 Victorio and his band attacked a stagecoach and mortally wounded retired Major General James J. Byrne.
Last stand and death
In October 1880, while moving along the Rio Grande in north-eastern Chihuahua, having sent Nana and Mangus to raid for food and ammunition, Victorio, with only a few warriors and even less ammunition, and his band were surrounded and killed by soldiers of the Mexican Army under Colonel Joaquin Terrazas in the Battle of Tres Castillos. An 1886 appendix for Papers Relating to the Foreign Nations of the United States states that, contemporaneously, the Tarahumara Scout credited with killing Victorio in 1880 was Mauricio Corredor. The Apache version states that Victorio actually committed suicide with a knife rather than face capture, historians such as Kathleen Chamberlain note that the Mexicans at the battle could not identify which body was Victorio's.
An Apache chief named "Vittorio" and loosely based on Victorio appears as a minor antagonist in Harry Whittington's 1963 novel Desert Stake-Out. Vittorio takes several people captive after learning that one of them murdered his brother, but later releases them upon learning that the killer is already dead and that the novel's protagonist, Merrick, is well regarded by the Mescaleros. In famous comics Blueberry, an Apache chief "Vittorio", again loosely based on Victorio is a recurrent character.