Oguttu was born in Buhehe sub-county, Butaleja District, to Wafula Olago, a veteran of World War II, and Lucia Aguttu. At the time of Oguttu’s birth, his father was working for a borehole-drilling company in Butaleja. A Samia by tribe, Wafula was raised in Mbajja Village, Lumino Sub-county, in present-day Busia District. The administrative area at that time was known as Bukedi District and included present-day Busia District, Tororo District, Pallisa District, Butaleja District, and Kibuku District. His name "Oguttu" in the Samia culture is given to someone born on the veranda or in the garden behind a house. Wafula grew up with five sisters and three brothers. His father died in 1960 when he was a primary two pupil. Because he was a bright student, he studied for free from primary to university despite being from a poverty-stricken family. He moved to Busoga in 1980 and fully transformed himself into a naturalized Musoga.
Oguttu started his working career in 1973 as a banking assistant at the Bank of Uganda. He was an editor for a Tanzania publishing house from 1977 until 1979. He went on to work as an assistant editor and then chief editor for Weekly Topic, an English language newspaper, from 1979 until 1992. He also served as an assistant lecturer at Makerere University between 1981 and 1985. He and others founded the Daily Monitor newspaper in 1992, eventually becoming the editor-in-chief before leaving in 2004. He is the executive chairman of Santa Lucia Basic School. Oguttu started his political career as a media politician in the 1970s when he was an assistant editor for Weekly Topic. He continued to be very active in media politics in the 1980s when he was then the editor in chief of the aforesaid newspaper. In the late 1980s, he held his first political office as an LCI Councillor for Nakawa Division. Government tried to have influence on his political columns in the early 1990s, but this prompted his resignation from Weekly Topic in 1992. He then founded the Daily Monitor that same year, as an anti-government newspaper at the time. He ran the Daily Monitor as the chief editor until his retirement in 2004. It was about that time that he co-founded the Forum for Democratic Change with Kiiza Besigye and others. He ran for his first parliamentary elections in 2006 on the FDC ticket, standing in the constituency of Bukhooli Country Central but ultimately losing to Fred Mukisa. In the 2011 general election he stood for the same seat, defeating NRM flagbearer Hajji Siraji Lyavala. He was unable to hold the seat in the 2016 general election however, losing out to the NRM's Solomon Silwany. On 31 January 2014, he was appointed Leader of Opposition in parliament. He also sat on the following parliamentary committees:
Oguttu is currently married to Alice Oguttu with five sons and two daughters. He however had a second wife, Freda, who died in July 2012 with whom he fathered two sons. He is of the Roman Catholic faith. Oguttu has supported farmers in Bugiri District on numerous occasions. At one time, he donated 30,000 coffee seedlings to farmers in his constituency to enhance household income, but put a condition that it was only "people with toilets" to benefit.
