Sabin went from Oxford to Washington, D.C., where he was press secretary for then U.S. Representative Robert Marion Berry. In March 2002, he moved to Little Rock to accept the position of director of development for the William J. Clinton Foundation. Two years later, Sabin became Associate Editor of the Arkansas Times, where he wrote cover stories and a weekly opinion column. During this time, he co-hosted a program on Arkansas public television called "Unconventional Wisdom". In 2007, he took the post of Associate Vice President for Communications at the University of Central Arkansas. Early in 2008, he was appointed Publisher of the Oxford American after the magazine was the victim of an embezzlement. Sabin was named to the FOLIO:40 list in 2009, and the Oxford American won the National Magazine Award for Video in 2011. Sabin announced in August 2013 that he was leaving the Oxford American to create the Arkansas Regional Innovation Hub, where he served as the founding executive director until the Innovation Hub became part of Winrock International in June 2016, and he was named senior director of U.S. Programs. He writes for The Huffington Post and serves on the board of directors for the Center for a Better South. He received the University of Arkansas Young Alumni Award in 2005 and was named to the Arkansas Business "40 Under 40" in 2003, and he has volunteered and served on the boards of directors for numerous community and nonprofit organizations and projects in Little Rock, including the Public Education Foundation, Little Rock Workforce Investment Board, Arkansas Advocates for Children & Families and the Arkansas Literacy Councils. He is married to Jessica DeLoach Sabin.
In 2012, Sabin was elected to the Arkansas House of Representatives from District 33, which includes downtown Little Rock and other neighborhoods. Both Arkansas Democrat-Gazette columnist John Brummett as well as Talk Business Quarterly named him among the top ten legislators of the 2013 legislative session, and the Arkansas Times called him the "Freshman of the session". Sabin was elected Chair of the 41-member bi-partisan Freshmen Caucus for the 89th General Assembly and he now holds the position of Assistant Speaker Pro Tempore for the 90th General Assembly. In 2014, he was named a 2014 Aspen Institute Rodel Fellow, and in 2015 he was named a winner of the NewDEAL "New Ideas Challenge" for his Working Families Opportunity Act. In the 2018 elections, Sabin ran for mayor of Little Rock. He finished in third place in the nonpartisan election, missing the runoff election, behind eventual winner Frank Scott Jr. and Baker Kurrus.