Wee started his political career as a member of the DAP contesting in 1986 general election and he was elected as member of parliament for the Bukit Bintang constituency in 1990 general election. In 1993, an injunction was issued against Wee and two other defendants from "printing, circulating or publishing any allegation of impropriety about the companies" after a case was brought by MBf alleging the defendants "unlawfully conspired with each other with the predominant purpose of injuring the companies by unlawful means". MBf later applied to have the defendants held in contempt of court for failing to obey the injunction. The application succeeded against Wee and another of his co-defendants and Wee was eventually ordered to pay a RM7,000 fine on appeal. The injunction against Wee brought by MBf was set aside in 2007 with the Court of Appeal ruling "The injunction was too wide in its terms and almost oppressive". He later sought damages against MBf and AmBank for loss of income due his inability to be an MP and the damage to his professional standing as a lawyer.
Wee was removed from the Bukit Bintang seat in 1995 after a controversial court case which nullified his re-election that year due to the fine he had received. He was ejected from the DAP in 1998 after being accused of damaging the party's image and went on to form the Malaysian Democratic Party. He later attempted to join Parti Keadilan Rakyat but was rejected by the party who stated at the time they did not want renegades from DAP. Due to the ruling against him in the 1995 court case, he was unable to contest the 1999 election. He contested the 2004 elections but did not even receive enough votes to keep his deposit. Wee Choo Keong was later referred to by V.K. Lingam in the Lingam tape. After the video tape was made public in 2007, Wee stated he intended to file for judicial review of the 1995 decision. Later, he also lodged a report with Suhakam over the tape arguing it demonstrated his human rights had been infringed.
People's Justice Party (PKR)
Before the 2008 general election, although still a member of the MDP, he was invited to join the PKR under the de facto leadership of Anwar Ibrahim and contest the Wangsa Maju constituency which he later won with a slim majority of 150.
Independent
In May 2010, Wee left PKR to sit in Parliament as an independent, citing disappointment with the PKR-led state government in Selangor's handling of the Dengkil sand mining scandal and the influence of what he called "little Napoleons and trendy leftists" in the party. He did not recontest his seat in the 2013 general election.
Election results
Initially, the Returning Officer had declared Wee Choo Keong as the elected representative for Bukit Bintang at the night of 25 April 1995. However, Lee Chong Meng filed his petition to nullify the election due to the fact that Wee had been convicted of the offence of contempt of Court and fined RM7,000, and hence disqualified to be a Member of Parliament under the provisions of Article 48 of the Federal Constitution. Election was declared null and void. The Federal Court had made such a controversial decision to declare Lee Chong Meng as the rightful winner. The appeal was dismissed by the Court of Appeal. No by-election was held by the Election Commission of Malaysia. Wee has contested and won the Wangsa Maju seat under the ticket of PKR but left to be an Independent in 2010.