In 1833, at the urging of his friends, including future Pennsylvania Governor Andrew Curtin, Bigler founded his own political newspaper, the Clearfield Democrat which supported Jacksonian democracy. In 1836, he married Maria Jane Reed and together they had five children. He sold the newspaper and joined his father-in-law's lumber business as co-partner. Between 1845 and 1850, his lumber business became the largest producer of building supplies on the West branch of the Susquehanna River, earning him the nickname "The Clearfield Raftsman". He served as a Jackson Democrat member of the Pennsylvania Senate for the 20th district from 1841 to 1846, including as Speaker from 1845 to 1846. He played a key role in the abolition of imprisonment for debt in Pennsylvania and the development of two insane asylums in Philadelphia and Harrisburg. He was a proponent of a central railroad from Philadelphia to Pittsburgh as competition to the B&O Railroad. His efforts resulted in a cross-state line in 1847 which was eventually sold and became the Pennsylvania Railroad. In 1849, he served as Pennsylvania revenue commissioner. He was elected the 12th Governor of Pennsylvania in 1851, defeating incumbent governor William F. Johnston. He and his brother John were the first brothers to serve as governors of two states simultaneously. He fought vigorously against wildcat banking and vetoed multiple bank charters and bank bills in his time as Governor. He lost popularity through his support of the Walker Tariff, the right of southern states to retain slavery, and the Kansas-Nebraska Act, and his enforcement of the 1850 Fugitive Slave Act. In 1855, he was defeated for re-election by James Pollock, the candidate of the newly formed Republican Party. After leaving the governor's office, he became president of the Philadelphia and Erie Railroad. He was elected to the United States Senate for Pennsylvania in 1856, and served until 1861. As a Senator, he supported pro-slavery measures to appease the South. He visited Kansas Territory in 1857, and thereafter advocated Kansas statehood under the pro-slavery Lecompton Constitution. He was a delegate to the 1860 Democratic National Convention and opposed the nomination of Stephen A. Douglas. During the secession crisis in 1861, he supported the compromise proposed by Kentucky Senator John J. Crittenden as a last ditch effort to avoid secession. He remained active in Pennsylvania politics and served as a delegate to the Pennsylvania constitutional convention in 1873 and as a key organizer of the 1876 Centennial Exposition in Philadelphia. He died on August 9, 1880 in Clearfield, Pennsylvania and was interred in Hillcrest Cemetery.
