William Middleton

• Billy Middleton
• George "Bay" Middleton
• Hastings (UK Parliament constituency)
• Ipswich (UK Parliament constituency)
• Northumberland (UK Parliament constituency)
• Sir William Fowle Middleton, 1st Baronet
• Sir William Middleton, 3rd Baronet
• Sir William Middleton, 5th Baronet
• William D. Middleton
• William James Middleton
• William Middleton (American football)
• William Middleton (bishop)
• William Middleton (by 1533–74 or later)
• William Middleton (pamphleteer)
• William Shainline Middleton