The Red Sox selected Jerez in the second round of the 2011 MLB Draft, signing him with a bonus of $443,700. He was the highest draft pick out of New York City since pitcher Jason Marquis in 1996. Jerez started his career as an outfielder, but was converted to a pitcher during extended spring training in 2014. He made his debut with the Gulf Coast League Red Sox in 2012 and collected hits in 11 of 12 games during one early-season stretch, batting as high as.340, but eventually he tapered off. He finished the year batting.248/.285/.310 with five stolen bases, three triples, and just six walks in 32 games. In 2012, Jerez started 32 games with the Short-Season A Lowell Spinners before missing the remainder of the season with hand injury. Prior to injury, Jerez batted.241 /.276/.277 with five RBIs and three stolen bases. Then in 2013, he appeared in 38 games and hit a paltry.176/.203/.235 in 38 games while playing right and center field for Lowell. But Jerez turned his career around after moving from outfield to pitcher in 2014. In that season, he posted a 3–1 record with a 2.22 ERA and one savecoming out of bullpen for the GCL Red Sox. He ended the season at Lowell, going 1–1 with a 4.50 ERA. In 2015 Jerez joined the Low A Greenville Drive, where he went 3–1 with a 2.06 ERA and three saves, striking out 43 in 39⅓ innings of work. He then gained a promotion to High A Salem Red Sox and was more dominant, posting a 1–0 record with a 0.73 ERA and 12 strikeouts in 12 innings. The Portland Sea Dogs would be the fifth stop in just a year and a half for Jerez, as he collected scoreless outings in 13 of 22 appearances since his Double-A debut on June 24, 2015. Overall, he went 5–3 with a 2.54 ERA and four saves in a career-high 41 games during the three stints. Jerez was added to the Red Sox40-man roster in November 2015. He remained with the Sea Dogs through 2016, featuring a 1–6 mark with a 4.71 ERA in 40 games, striking out 65 and walking 30 in 65 innings, while earning a selection to the Eastern League All-Star Game. He opened 2017 at Portland, where he went 2–0 with four saves and 3.10 ERA in 29 games before joining the Triple-A Pawtucket Red Sox in the month of August. He appeared in nine games with the PawSox, going 0–2 with a 3.75 ERA in 12 innings. He finished the year rated as the Red Sox' No. 21 prospect, according to MLB.com. Jerez began the 2018 season with Triple-A Pawtucket.
Los Angeles Angels
On July 31, 2018, the Red Sox traded Jerez and pitcher Ty Buttrey to the Los Angeles Angels for second basemanIan Kinsler. On August 7, 2018, the Angels called up Jerez and he made his major league debut pitching two scoreless innings against the Detroit Tigers. For 2018 with the Angels, he was 0-0 with a 6.00 ERA, and 15 strikeouts in 15 innings.