Homer and Marcia Bigelow are a happily married couple. Visiting novelist J. Hugh Ramsey considers himself both too wise to ever marry and, through hubris, qualified to offer his own wild theories on what constitutes a happy marriage. He had thus written a best selling novel titled Marriage, the Living Death. Ramsey decides that the Bigelow marriage could not possibly be as perfect as it appears, and convinces Homer that his wife must be secretly unhappy because she had never had the opportunity to forgive the morally spotless Homer for any misdeed. Wishing to please, Homer decides to involve himself in a trist so that Marcia would then have something for which she could forgive him. He chooses French actress Renée La Journée who is performing nearby. Ramsey learns of the affair and discovers that the La Journée turns out to be the one love of his life that he had lost years earlier.
Lawrence Journal-World called the film "a delightful and hilarious comedy of married life". They wrote that Charles Ruggles and Mary Boland "carry the lead roles in inimitable manner which has endeared them to millions", and that the film marked a return to film for actress Vivienne Osborne after a two-year absence. Evening Independent noted that a film combination of Charles Ruggles and Mary Boland is always irresistible, and wrote that the film "kept the preview audience laughing from beginning to the last fade-out". In consideration of the three stars, they wrote "Ruggles, Boland and Menjou make a rollicking comedy trio", and predicted that the film "should play a merry tune at boxoffices". In October 1936, The Sunday Morning Star listed the film as one of its 'Best Bets of the Week'. Conversely, Pittsburgh Post-Gazette advised that fans of Charles Ruggles and Mary Boland would be in for a "considerable let-down" when watching the film. In examining the film in comparison to previous films where Ruggles and Boland reprised roles where they were husband and wife, they wrote of Wives Never Know that "it is a listless, laborous little comedy that resembles the result of a scavenger hunt at the old Mack Sennett Studios." They offered that there were the expected laughs to be found in any film involving Ruggles and Boland, but that the storyline itself possessed few comic qualities, and that left to their own resources, the co-stars "falter and fumble through six or seven reels of makeshift humor." The New York Times made note of the ongoing screen partnering of Charles Ruggles and Mary Boland, and that the film in offering Ruggles' "familiar timid-husband sequences" and Boland's "usual number of stock Bolandisms", seems to be holding "a sacrifice auction sale..." "...at a considerable reduction in humor." In addressing the film plot, they felt it was "merely an antiquated type of stage farce enacted before a camera". However, they made special note of the contribution of Adolphe Menjou, who in the role of a visiting author, was "quixotic as ever" in his character's "commendable effort to break up the Ruggles-Boland marriage." They commended that the entire cast gave their best efforts, and that "even the urbane Mr. Menjou falls into the ditch, as it were, unreservedly, without holding back a shred of himself."
