YIPF6
Protein YIPF6 is a protein that in humans is encoded by the YIPF6 gene.
In mice, a null allele of YIPF6 has been found to cause intestinal inflammation resulting in spontaneous colitis and ileitis by impairing intestinal homeostasis. The impairment was due to defects in the formation and secretion of large secretory granules from goblet and Paneth cells. Because the X-linked YIPF6 mutation resulted in spontaneous disease, it has been suggested that it may increase susceptibility to inflammatory bowel disease in humans, particularly in males.
