The regiment left New York from its Camp Astor on Rikers Island on August 21, 1861. The regiment embarked upon the steamer Kill Van Kull by which the men and the camp equipment were transported the Elizabethport New Jersey, from where the regiment was transported to Washington, D.C. by the Central Railroad of New Jersey. The regiment arrived in Baltimore at 9am the next morning where they disembarked in order to change trains. On their march through the town the regiment was cheered by the crowd. By 1pm the regiment and its equipment had been transferred to the carriages at the south bound depot and by late that day the regiment arrived in Washington. On August 23, the Anderson Zouaves marched through Washington and on to Meridian Hill where they were reviewed the next day by William H. Seward. On September 13, 1861, the regiment was brigaded with the 6th New Jersey, the 55th New York, aka the Gardes Lafayette and the 102nd Pennsylvania Infantry Regiment, under the command of General John J. Peck. On September 26, the regiment broke camp in abeyance to an order received the previous evening and marched two or three miles to the village of Kalorama on Rock Creek, where, on the rocky, sloping ground of Swartz' Farm the brigade established Camp Holt. After two weeks in this location, October 9, 1861, the Anderson Zouaves along with the rest of Peck's brigade was moved to Tennallytown where it replaced McCall's Division of the Pennsylvania Reserves, which had crossed the Chain Bridge into Virginia the day previous. On October 1, 1861, while at Camp Tennally, the regiment's Lieutenant Colonel, William S. Tisdale, was discharged due to disability and was replaced by David J. Nevin, the captain of company "D". The Anderson Zouaves spent the winter in camp at Tennallytown, until it took part in the Advance on Manassas on March 10, 1862. The regiment marched to Prospect Hill where it lay for three days, before returning to its old camp at Tennallytown. On March 26, the regiment deployed to McClellan's Peninsula Campaign aboard transports at Georgetown harbor. The Anderson Zouaves fought at Gettysburg. The regiment was mustered out at Fort Schuyler, New York Harbor, on August 30, 1865. It lost during its term of service 3 officers and 85 enlisted men killed and mortally wounded, and 2 officers and 82 enlisted men by disease; total 172. Three members of the regiment were awarded the Medal of Honor: Edward Brown, Jr., James R. Evans and Charles. E. Morse.