ADE (chemotherapy)


ADE is a chemotherapy regimen most often used as an induction or consolidation regimen in acute myelogenous leukemia, especially in poor-risk patients or those refractory to the standard first-line induction with standard "7+3" regimen or who are relapsed after the standard chemotherapy.
ADE regimen consists of three drugs:
  1. Ara-C - an antimetabolite;
  2. Daunorubicin - an anthracycline antibiotic that is able to intercalate DNA and thus disrupt the cell division cycle, preventing mitosis;
  3. Etoposide - a topoisomerase inhibitor.

    Dosing regimen