Hempel's first film appearance was in the Hammer Horror filmThe Kiss of the Vampire. In 1969, she appeared in the James Bond filmOn Her Majesty's Secret Service as one of the "angels of death". Thereafter she appeared in several films including Scars of Dracula, The Magnificent Seven Deadly Sins, Go for a Take, Tiffany Jones, Russ Meyer's controversial, soft pornographic film Black Snake, Double Exposure, and Lady Oscar. In the 1970s, Hempel appeared in one episode of the BBC series The Lotus Eaters and she also auditioned for the part of Jo Grant in Doctor Who and appeared in the science-fiction TV series' UFO and .
After finishing acting, Hempel has embarked in a career as a hotelier and interior designer. In 2002, she was ranked by Architectural Digest as one of the top 100 interior designers and architects in the world.
Hotels
Hempel has established four hotels. Blakes Hotel was created in 1978 as one of the world's first luxury boutique hotels. Based in South Kensington, it is well known for its design, quality of service and privacy. The hotel's restaurant has become a destination in its own right, featuring a fusion of Hempel's own favourite cuisines – Japanese and Italian. Her second hotel, the Hempel Hotel, was noted as a minimalist hotel. Blakes Amsterdam was opened in 1999, drawing inspiration from Amsterdam's historic Dutch East India Company. Hempel currently works as a silent adviser in her hotel company and is working on other hotels in Beirut, Santiago Chile, Lisbon, Istanbul and a new hotel for Baccarat in Rabat. Her showcase hotel "Warapuru" is set in the Brazilian rainforest overlooking the ocean, but opening has been delayed several years. Other recent openings include The Grosvenor House Apartments, on Park Lane and La Suite West in Bayswater, both in London. Blakes Hotel was recently sold to investors, following a renovation by the Anouska Hempel Design there are plans to expand the brand with Blakes Shoreditch. Anouska Hempel Design's projects that opened recently include Six Senses Duxton, Singapore, and Monsieur George, Paris.
Other designs
Hempel's restaurant designs range from modern minimalist to theatrical. Her restaurant projects include Shy in Jakarta and in London. She has designed retail stores for Van Cleef & Arpels and Louis Vuitton, for whom she designed their flagship Paris store and items such as luxury fountain pens and ballpoint pens with leather and lacquer surface. Other stores include Henry Cottons in Milan and Lokum in London. Hempel has also designed two yachts: "Beluga", her own yacht, a renovated 10 berth Turkish Gulet which has black sails; and San Lorenzo, a sleek minimal design for a private commission. Hempel has taken private commissions for homes and landscapes, most recently a garden in honour of Princess Margaret in Oxford. Her own homes, Cole Park near Malmesbury, Wiltshire and a large house in Ennismore Gardens, London, regularly appear in design magazines. Through a boutique in South Kensington, she has designed haute couture clothes for many famous women, including Princess Diana and Princess Margaret of the Royal Family.