After graduating, Leone was hired as an intern at Bon Appétit as a test kitchen assistant, a role which required him to perform "all the shopping, all the cleaning and certainly all the dishes", leading him to describe his position as "a glorified dishwashing job". He was later offered a full-time position at the magazine, eventually working his way up to Test Kitchen Manager. In 2016, amid an effort by Bon Appétit to increase its YouTube presence, creative directorAlex Grossman conceived of a web series that would follow Leone in the magazine's test kitchen. The first video, which followed Leone making kombucha, was shot and subsequently shelved for eight months before camera operatorVincent Cross convinced the magazine to post the video. The video, which would become the first episode of It's Alive with Brad, debuted on October 21, 2016. It's Alive with Brad developed into a regular series that follows Leone as he creates food with microbial food cultures, though later episodes additionally focus on more general recipes and on-location activities. The series stars Leone and is filmed, produced, and edited by Matt Hunziker. Cross previously filmed and produced the show until he left for Binging with Babish in February 2019. It's Alive has been praised for its comedic editing and for Leone's laid-back cooking style, having been described as "part cooking show, part travel show, part Pop-Up Video and part continuous blooper reel". The loose and personality-driven style of It's Alive, along with Gourmet Makes starring Claire Saffitz, are noted as contrasting the "curated posh" brand of Bon Appétit and were described by Forbes as having "changed the way Condé Nast approaches online video". In late 2018, Leone transitioned roles at Bon Appétit, moving out of his role as Test Kitchen Manager to focus exclusively on creating videos. An It's Alive spin-off series, It's Alive: Goin' Places, was launched in 2019 on Bon Appétit's dedicated streaming channel; the first season follows Leone in Central Texas, while the second season follows Leone in Hawaii. That same year, Leone was nominated at the 11th Shorty Awards in the category "Best in Food" for his work on It's Alive.
Personal life
Leone resides in New Jersey with his partner, Peggy, and two sons, Callen and Griffin.