Nassib attended Malvern Preparatory School in Malvern, Pennsylvania, where he was a three-year letterman in football. He played as an offensive tackle and defensive end. He helped lead Malvern Prep to a 7–4 record in both his junior and senior years. Nassib also lettered twice in basketball and three times in track & field. As a senior, he was selected team captain in basketball, helping lead the Friars to a 24–7 record and an Inter-Ac Championship.
College career
Nassib joined the Penn State University as a walk-on in 2011. After not playing his first two years, Nassib played in 10 games as a sophomore in 2013. He recorded 12 tackles and one sack. As a junior, he appeared in all 13 games and had seven tackles and one sack. He became a starter for the first time his senior year in 2015. Nassib reached 10 sacks in only six games to start the year. Because of his stellar 2015 season, he was named the Big TenNagurski-Woodson Defensive Player of the Year for 2015, was presented with the Hendricks Award for the nation's top defensive end, and also given the Lombardi Award for being the best college football lineman or linebacker. Nassib was also a finalist, for several other awards, including the Bronko Nagurski Trophy, the award given to the best defensive player in the country, along with the Burlsworth Trophy given to the nation's best player who started their career as a walk-on. USA Today honored Nassib as a Second-Team All-American.
Professional career
Cleveland Browns
Nassib was selected by the Cleveland Browns in the third round of the 2016 NFL draft with the 65th pick. On June 28, Nassib signed a four-year contract worth about $3.2 million, with signing bonus worth approximately $890,000. In his first game as a professional, against the Philadelphia Eagles, Nassib recorded one sack, three tackles, and one defended pass, and earned a nomination for Pepsi NFL Rookie of the Week. Nassib was waived by the Browns on September 2, 2018.
On September 3, 2018, Nassib was claimed off waivers by the Tampa Bay Buccaneers. He set career highs in both sacks and tackles for loss in 2018, both higher than his career totals in both categories going into the season.
On March 27, 2020, Nassib signed a three-year, $25 million contract with the Las Vegas Raiders.
Personal life
Carl is the son of Mary and Gilbert Nassib. His father, Gilbert Nassib, played college football at the University of Delaware. He has four siblings, including two brothers, John and Ryan, and two sisters, Carey and Paige. Ryan, who is three years older, played college football for Syracuse University and was a quarterback in the NFL and is currently a free agent.