Billingsley made his Major League Baseball debut with the Los Angeles Dodgers on June 15, 2006, against the San Diego Padres at Petco Park in San Diego, California. In his debut, Billingsley started on the mound, and pitched 5.1/3 innings and surrendered 6 hits and 2 runs while striking out three. He even knocked in two runs in his first official at-bat to help his cause. His debut was considered a success as the Dodgers went on to defeat the Padres 7–3. Billingsley remained in the starting rotation for the rest of the season, but started 2007 in the bullpen. He pitched well in relief and was returned to the starting rotation on June 21 after season ending surgery placed Jason Schmidt on the disabled list. In 2008, Billingsley elevated to one of the top pitchers in the National League while demonstrating his potential as an ace. He finished the year with a 16–10 record, was 5th in the NL with 201 strikeouts, and recorded an ERA of 3.14 and a WHIP of 1.34 in 200.2 innings pitched. Billingsley pitched his first career complete game shutout against the San Francisco Giants on July 30, 2008, allowing five hits and recording eight strikeouts without allowing a walk. On September 6, Billingsley faced Arizona ace Brandon Webb and helped to hold him off long enough for a Manny Ramirez homer, and a 7–2 win, his 14th of the season. Billingsley also started 3 postseason games for the Dodgers in 2008. In his first postseason appearance, Billingsley pitched a strong innings, while allowing just one run against the Chicago Cubs. The Dodgers won the game 10–3. However, in his next two starts, Billingsley was not nearly as effective. Lasting only innings, Billingsley was torched for 8 runs in an 8–5 loss to the Philadelphia Phillies in Game 2 and innings, while giving up 3 earned runs, in Game 5 of the 2008 NLCS. He received some criticism for not brushing back to Phillies batters when Dodgers hitters were knocked down several times. On November 21, 2008, Billingsley slipped on ice outside his South Heidelberg Township home, and suffered a spiral fracture of the fibula in his left leg. However, the injury was healed by the time spring training began. In 2009, Billingsley started well, winning his first five decisions and posted a 7 inning, 11 strikeout performance against the San Francisco Giants on April 13. On July 5, 2009, Billingsley hit his first career home run off Josh Banks in a 7–6 Dodgers win against the San Diego Padres. He was selected to the 2009 National League All-Star Team. However, he struggled in the second half of the season and finished the year 12–11 with a 4.03 ERA in 32 starts and pitched out of the bullpen in the playoffs. In 2010, he had a solid season, finishing 12–11 with a 3.57 ERA in 31 starts and also pitched one complete gameshutout, on July 21 against the San Francisco Giants. Billingsley signed a 3-year $35 million extension during spring training in 2011. The season, however, was a disappointment. With an 11–11 record, it was the first season he failed to finish with a winning record. His ERA was 4.21, and his 152 strikeouts were the fewest since becoming a full-time starter in 2008. In a loss to the Arizona Diamondbacks on July 7, 2012, Billingsley recorded his 1,000th strikeout and in doing so, became the 12th Dodgers pitcher to reach the milestone. Billingsley finished the 2012 season with a 10-9 record and 3.55 ERA in 25 starts. On September 5, 2012, it was announced that Billingsley had a partial tear in his ulnar collateral ligament, the type that usually requires Tommy John surgery. Billingsley was shut down for the rest of the 2012 season. Rather than undergoing off-season surgery and missing the entire 2013 season, Billingsley chose to try to treat the injury with platelet-rich plasma injections. However, after just 2 starts in 2013 he felt pain in the elbow again. An MRI revealed that the tear had returned. Billingsley underwent Tommy John surgery on April 24 and missed the rest of the 2013 season. Billingsley rehabbed his injury in an attempt to return in 2014, but after a couple of minor league rehab starts he experienced some discomfort in his elbow. An MRI revealed that he had torn his flexor tendon in the elbow and he was shut down again. Later in 2014, Billingsley underwent a season-ending surgery to repair this same torn flexor tendon. The Dodgers declined his 2015 option on October 31, 2014, making him a free agent.
Philadelphia Phillies
Billingsley signed a one-year deal with the Philadelphia Phillies on January 29, 2015. He began the 2015 season on the 15-day disabled list to recover from his previous elbow surgery and made his debut with the Phillies on May 5, 2015.
Pitching style
Billingsley was a versatile pitcher, throwing four pitches with regularity and another two infrequently. He led with a four-seam fastball at 90–93 mph and a sinker at 90–92 mph. He featured a cut fastball in the upper 80s, an occasional slider in the mid 80s, a changeup in the mid-high 80s, and a curveball that is usually in the upper 70s. Billingsley typically worked right-handed hitters with all of his pitches except for his slider and changeup. Against lefties, he used the changeup more frequently. He used his curveball in many two-strike counts once he established the strike zone with fastballs.