Chromosome 8


Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 145 million base pairs and represents between 4.5 and 5.0% of the total DNA in cells.
About 8% of its genes are involved in brain development and function, and about 16% are involved in cancer. A unique feature of 8p is a region of about 15 megabases that appears to have a high mutation rate. This region shows a significant divergence between human and chimpanzee, suggesting that its high mutation rates have contributed to the evolution of the human brain.

Genes

Number of genes

The following are some of the gene count estimates of human chromosome 8. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies. Among various projects, the collaborative consensus coding sequence project takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.
Estimated byProtein-coding genesNon-coding RNA genesPseudogenesSourceRelease date
CCDS6462016-09-08
HGNC6562425392017-05-12
Ensembl6701,0526132017-03-29
UniProt7032018-02-28
NCBI7198486822017-05-19

Gene list

The following is a partial list of genes on human chromosome 8. For complete list, see the link in the infobox on the right.

Diseases and disorders

The following diseases and disorders are some of those related to genes on chromosome 8:
Chr.ArmBandISCN
start
ISCN
stop
Basepair
start
Basepair
stop
StainDensity
8p23.30115gneg
8p23.2115331gpos75
8p23.1331690gneg
8p22690992gpos100
8p21.39921179gneg
8p21.211791380gpos50
8p21.113801639gneg
8p12163918971gpos75
8p11.2318972041gneg
8p11.2220412156gpos25
8p11.2121562343gneg
8p11.123432472acen
8q11.124722645acen
8q11.2126452817gneg
8q11.2228173033gpos75
8q11.2330333277gneg
8q12.132773493gpos50
8q12.234933622gneg
8q12.336223809gpos50
8q13.138093938gneg
8q13.239384096gpos50
8q13.340964312gneg
8q21.11431245451gpos100
8q21.1245454628gneg
8q21.1346284858gpos75
8q21.248584959gneg
8q21.349595289gpos100
8q22.152895577gneg
8q22.255775692gpos25
8q22.356925922gneg
8q23.159226152gpos75
8q23.261526267gneg
8q23.362676611gpos100
8q24.1166116726gneg
8q24.1267266942gpos50
8q24.1369427244gneg
8q24.2172447431gpos50
8q24.2274317661gneg
8q24.2376617804gpos75
8q24.378048250gneg