De Ayala
de Ayala may refer to:
- Adelardo López de Ayala y Herrera, Spanish writer and politician
- Jaime Zobel de Ayala, prominent Filipino businessman and photographer
- Juan de Ayala, Spanish naval officer
- Pero López de Ayala, Castilian statesman, historian, poet, chronicler, chancellor, and courtier
- Pedro de Ayala, Spanish diplomat
- Pilar López de Ayala, Spanish film actress
- Ramón Pérez de Ayala, Spanish writer
