Demoxytocin


Demoxytocin , also known as desaminooxytocin or deaminooxytocin, as well as 1-oxytocin, is an oxytocic peptide drug that is used to induce labor, promote lactation, and to prevent and treat puerperal mastitis. Demoxytocin is a synthetic analogue of oxytocin and has similar activities, but is more potent and has a longer half-life in comparison. Unlike oxytocin, which is given via intravenous injection, demoxytocin is administered as a buccal tablet formulation.
The drug was first synthesized in 1960 and was introduced into clinical practice in 1971 by Sandoz. It is marketed in several European countries, including Italy, Czech Republic, and Poland. It has the amino acid sequence Mpa-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2, and is an analogue of oxytocin wherein the leading cysteine is replaced with β-mercaptopropionic acid.

Uses and Impact

Labour was induced or stimulated after random allocation of the mothers to one of three oxytocics.Using as models, the neurohypophyseal nonapeptide hormone oxytocin and its analogue deaminooxytocin, several directed routes to formation of sulfur-sulfur bridges have been developed and evaluated. PGE2 tablets were given to 109 parturients and demoxytocin resoriblets to 84. Use of oral oxytocics for stimulation of labor in cases of premature rupture of the membranes at term. A randomized comparative study of prostaglandin E2 tablets and demoxytocin resoriblets. The efficacy of oral PGE2 tablets and buccal demoxytocin for the induction of labor in cases of premature rupture of the membranes after the 37th week of gestation has been evaluated in a prospective, randomized investigation of 193 women.