Dihomo-γ-linolenic acid


Dihomo-γ-linolenic acid is a 20-carbon ω−6 fatty acid. In physiological literature, it is given the name 20:3. DGLA is a carboxylic acid with a 20-carbon chain and three cis double bonds; the first double bond is located at the sixth carbon from the omega end. DGLA is the elongation product of γ-linolenic acid. GLA, in turn, is a desaturation product of linoleic acid. DGLA is made in the body by the elongation of GLA, by an efficient enzyme which does not appear to suffer any form of inhibition. DGLA is an extremely uncommon fatty acid, found only in trace amounts in animal products. DGLA production from GLA is enhanced when high levels of alpha-linolenic acid are present, blocking the arachidonic acid pathway.

Biological effects

The eicosanoid metabolites of DGLA are:
All of these effects are anti-inflammatory. This is in marked contrast with the analogous metabolites of arachidonic acid, which are the series-2 thromboxanes and prostanoids and the series-4 leukotrienes. In addition to yielding anti-inflammatory eicosanoids, DGLA competes with AA for COX and lipoxygenase, inhibiting the production of AA's eicosanoids.
Taken orally in a small study, DGLA produced antithrombotic effects. Supplementing dietary GLA increases serum DGLA, as well as serum AA levels. Cosupplementation with GLA and EPA lowers serum AA levels by blocking Δ-5-desaturase activity, while also lowering leukotriene synthesis in neutrophils.
is a rich source of γ-linolenic acid—the dietary precursor to DGLA.