The Tigers purchased Machado's contract after the 2012 season, adding him to their 40-man roster. He was designated for assignment on December 4, 2013, to make room on the 40-man roster for Joe Nathan. He was added to the 40-man roster again on November 20, 2014. During the 2014 season, he hit.305 with five home runs and 32 RBI, with a.965 fielding percentage in 90 games with the Double-AErie SeaWolves. He also appeared in 41 games with the Class-A Advanced Lakeland Flying Tigers, hitting.252 with one home run and eight RBI, with a.972 fielding percentage. Machado was named the Eastern LeaguePlayer of the Month for the month of August 2014. He hit.410 with six doubles, three home runs, 17 runs scored, 15 RBI, five stolen bases, a.515 on-base percentage and a.590 slugging percentage in 25 games during the month. He ranked first among all Eastern League hitters in batting average, on-base percentage and OPS, tied for second in hits, third in slugging percentage and walks.
Detroit Tigers
Machado was called up from the Triple-AToledo Mud Hens on May 24, 2015. He made his major league debut the next day in a game against the Oakland Athletics. Prior to being called up, Machado was hitting.274 with one home run and 16 RBIs in 40 games with the Mud Hens. On May 27, Machado got his first career major league hit, a single off of Sean Doolittle of the Oakland Athletics in the sixth inning. On September 1, 2015, Machado was named to the International League post-season All-Star game. Machado was hitting.259 with 47 RBIs, 15 steals and a.640 OPS in 124 games with the Mud Hens. His.976 fielding percentage ranked among the best for International League shortstops. Machado was named the Venezuelan Winter League Player of Week for the week ending October 26, 2015. While playing for Leones del Caracas, Machado batted 22-for-57 with seven doubles, three home runs and 11 RBIs. Machado spent most of 2016 with the Toledo Mud Hens, appearing in only eight September games for the Detroit Tigers. Machado made the 2017 opening day roster for the Tigers. On July 6, he hit his first Major League home run off Chris Stratton of the San Francisco Giants. Machado would go on to hit.259 in 166 at-bats for the 2017 Tigers. Machado again made the Tigers' opening day roster in 2018. He hit a ninth-inning walk-off home run on April 18, lifting the Tigers to a win over the Baltimore Orioles, but was designated for assignment on July 4 after batting.206 in 67 games with only that one home run. After clearing waivers unclaimed by any other major league team, Machado could have elected free agency but chose to accept the assignment to AAA Toledo on July 8. He declared free agency on October 3, 2018.
On March 29, 2019, Machado signed a minor league deal with the Chicago Cubs and was assigned to AAA Iowa Cubs. He elected free agency on November 4, 2019.
Lotte Giants
On November 22, 2019, Machado signed one-year contract with the Lotte Giants of the KBO League.
