Perkins started his professional career in the 2005–06 season in the Japanese League, where he played for Toyota Alvark. He was named the MVP of the league, after leading his team to the championship. In the final game, Perkins had 19 points, 11 rebounds, and 6 assists. Perkins then signed with the German League clubEWE Baskets Oldenburg for the 2006–07 season. He averaged 12 points, 3.8 rebounds, and 4.1 assists in 27 minutes per game. In the 2007–08 season, Perkins led his team, Bree, to the Belgian League's final. He had an outstanding season. He finished the season averaging 15.8 points, 5.3 rebounds, 5.7 assists, and 3.1 steals in 31 minutes per game. For the 2008–09 season, Perkins signed with the Israeli Super League club Maccabi Haifa. He averaged 17 points, 6.3 rebounds, 5.3 assists, and 3 steals in 31 minutes per game. He had his best game against Ashkelon, finishing the game with 27 points, 7 rebounds, 7 assists, 4 steals, and 2 blocks. He was rewarded for his efforts with the Super League's MVP award. Perkins was named the MVP of his league in two out of his first four pro seasons. In August 2009, Perkins was invited to join the senior men's Russian national team. As citizenship was a prerequisite to joining the team, Perkins was offered Russian citizenship. He decided however not to take Russian citizenship. He then returned to the Israeli Super League, and signed with the league's defending champions Maccabi Tel Aviv. During the 2010–11 season, Perkins earned the nickname "who if not", due to his uncanny knack for coming up with loose balls, and for the way the Hebrew speaking game announcers constantly used the phrase, "who if not, Doron Perkins". On March 29, 2011, during game 3 of the EuroLeague playoff series between Maccabi Tel Aviv and Caja Laboral, for the ticket to the EuroLeague Final Four, Perkins suffered an injury to his right knee. A medical examination later showed that he suffered two tears in his Meniscus, in his ACL and MCL, and he subsequently underwent surgery to repair the damaged knee. A prognosis of nine months rehabilitation time was published in the media. In early February 2012, Perkins returned to the court, after nearly one year off from basketball. He signed with the Italian League club Cantù, and played in his first EuroLeague game against Spanish League power Barcelona. Perkins finished the game with 12 points, 7 rebounds, 5 assists, and 2 steals. Perkins was also named the player of the week in his second week in the Italian League. He then signed with the Ukrainian League club Donetsk. After playing in the Chinese Basketball Association with Foshan Long Lions, Perkins joined the Greek League club Olympiacos in February 2013. With Olympiacos, he won the 2012–13 season championship of the EuroLeague. He was released by Olympiacos in May 2013. He signed a contract with Beşiktaş Integral Forex on September 30, 2013. On September 6, 2014, Perkins signed a one-year contract with the Spanish team Laboral Kutxa Vitoria. On December 12, 2014, he parted ways with Laboral. On January 27, 2015, he signed with Krasny Oktyabr of Russia for the remainder of the season. However the next month he was released, before making official debut for the team. In August 2015, Perkins signed with Turkish club Yeşilgiresun Belediye for the 2015–16 BSL season. On December 11, 2016, Perkins signed with Sanat Naft Abadan of the Iranian Super League. On August 18, 2017, Perkins signed with Goyang Orions of the Korean Basketball League.
