Search
Menu
Home
Sources
About
Contacts
GNF6702
GNF6702
is the name for a
broad-spectrum
antiprotozoal drug
invented
by
researchers
working
at the
Genomics Institute of the Novartis Research Foundation
in
2013
, with
activity
against
leishmaniasis
,
Chagas disease
and
sleeping sickness
. These three diseases are
caused
by related
kinetoplastid
parasites, which
share
similar biology. GNF6702 acts as
allosteric
proteasome inhibitor
which was
effective
against
infection
with any of the three
protozoal
diseases in
mice
, while having little
evident
toxicity
to mammalian
cells
.