GOLT1B


Vesicle transport protein GOT1B is a protein that in humans is encoded by the GOLT1B gene.
Got1p is a protein that aides in vesicle transport through the Golgi apparatus of the cell. Got1p has a calculated mass of 15.4 kDa and consists of 138 residues. It is believed that the protein is a tetra-spanning membrane protein, and is evolutionarily conserved. Homologes of the protein have been found in Caenorhabditis elegans, Plasmodium falciparum, and in mammals. GOT1 is normally associated closely with Sf2p , which is another protein of similar function. In vivo, It has been found that the removal of these two proteins results in defects in endosome-Golgi traffic and ER-Golgi traffic. In vitro, the removal of got''1 specifically, results in a defect in ER-Golgi transport in relation to vesicle tethering to Golgi membranes. The exact contribution that the protein has towards vesicle tethering is still a mystery, however, it is suspected that Got1p is involved in the release of Ca2+ in the Golgi membranes, causing ion channels associated with vesicle tethering to be affected.