GPR75
Probable G-protein coupled receptor 75 is a protein that in humans is encoded by the GPR75 gene.Function
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.
GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study, the chemokine CCL5 has been shown to stimulate calcium mobilization and inositol triphosphate formation in GPR75-transfected cells.
Recently, 20-hydroxyeicosatetraenoic acid, a bioactive eicosanoid formed by ω-hydroxylation of arachidonic acid has been shown to mediate its prohypertensive effects on the vasculature through activation of GPR75 signalling. This study by Dr. Schwartzman's laboratory at New York Medical college, one of the pioneers in study of 20-HETE biology, has opened new insights into the field of GPR75 pharmacology.
