Ilomastat


Ilomastat, is a broad-spectrum matrix metalloproteinase inhibitor.
This chemotherapy agent is considered to have application in skincare products for its antiaging properties.
Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.
Examples of enzymes that ilomastat inhibit include rabbit MMP9, thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase produced by the bacterium Bacillus anthracis.