McGee made his minor league debut in, and spent 2004 and with the Princeton Devil Rays and the Hudson Valley Renegades. In, McGee spent the year with the Southwest Michigan Devil Rays. He played with both the Vero Beach Devil Rays and the Montgomery Biscuits in. he spent the entire with the Montgomery Biscuits, going 6–4 with 3.94 ERA. McGee was rated by Baseball America as the third-best organizational prospect for Tampa Bay Rays and 15th overall MLB prospect in 2008. In 2007, he was ranked 5th in the Rays' organization and 37th overall in all of baseball. McGee is nicknamed "Clockhands". He earned the nickname due to his unconventional windup. McGee had Tommy John surgery on July 8, 2008. McGee was promoted to the MLB for the first time on September 14, 2010. He made his MLB debut that night against the New York Yankees, walking three batters and striking out Derek Jeter for his first MLB strikeout. McGee made the Rays MLB roster after spring training in 2011, but he was sent down to the team's Class AAA minor league affiliate after 11 appearances. In the last few months of the 2014 season, McGee became the Rays' closer. He finished the season with 19 saves. After undergoing elbow surgery to remove "loose bodies" in December 2014, McGee spent the early portion of the 2015 season with the Class AAA Durham Bulls. He underwent knee surgery for a torn meniscus in late August, ending his season.
Colorado Rockies
On January 28, 2016, McGee and Germán Márquez were traded to the Colorado Rockies for Corey Dickerson and Kevin Padlo. McGee had a 4.73 ERA in the 2016 season. McGee and the Rockies avoided salary arbitration on December 3, 2016, by agreeing to a $5.9 million contract for the 2017 season. In 2017, McGee had an 0-2 win-loss record, a 3.61 ERA, and three saves in 62 games. On December 15, 2017, McGee signed a three-year, $27 million contract with the Rockies. The following season, McGee posted the worst season of his career, setting a career worst 6.49 ERA in 61 games. McGee bounced back in 2019 despite spending time on the disabled list, posting an ERA of 4.35 in 45 games. McGee was released by the Rockies on July 17, 2020.
On July 21, 2020, McGee signed a one-year contract with the Los Angeles Dodgers.
Personal life
Jake and Morgan McGee have been married since December 2009. As of late 2015, they live in Tampa, Florida. For the last several years, the couple has purchased Christmas presents for foster children in Reno and Tampa.