Player | Age | Position | Team | Cause of death | Year | Ref |
| 22 | Pitcher | Los Angeles Angels of Anaheim | car crash | 2009 | |
| 26 | First baseman | Boston Red Sox | pulmonary embolism | 1955 | |
| 28 | Pitcher | Milwaukee Brewers | heart attack | 1982 | |
| 23 | Pitcher | Baltimore Orioles | complications from use of ephedra | 2003 | |
| 22 | Pitcher | Middletown Mansfields | tuberculosis | 1873 | |
| 28 | Catcher | Boston Beaneaters | suicide, cut his own throat | 1900 | |
| 26 | Pitcher | Chicago Cubs | influenza | 1890 | |
| 31 | Third baseman | Boston Braves | car crash | 1924 | |
| 29 | Outfielder | Minnesota Twins | leukemia | 1967 | |
| 36 | Pitcher | Pittsburgh Pirates | appendicitis | 1949 | |
| 27 | Outfielder | California Angels | homicide, gunshot | 1978 | |
| 38 | Pitcher | Chicago Cubs | stomach hemorrhage | 1930 | |
| 23 | Shortstop | Washington Senators | purpura hemorrhagia | 1906 | |
| 29 | Shortstop | Cleveland Indians | struck on head by a pitch during a game | 1920 | |
| 21 | Pitcher | San Francisco Giants | plane crash | 1969 | |
| 38 | Outfielder | Pittsburgh Pirates | plane crash | 1972 | |
| 29 | Pitcher | New York Yankees | lung cancer | 1916 | |
| 28 | Second baseman | Brooklyn Dodgers | typhoid fever | 1892 | |
| 31 | Pitcher | Cleveland Indians | boat accident | 1993 | |
| 28 | Catcher | Louisville Colonels | tuberculosis | 1888 | |
| 25 | Outfielder | San Diego Padres | car crash | 2002 | |
| 40 | First baseman | Cincinnati Reds | appendicitis | 1924 | |
| 35 | Outfielder | Washington Senators | drowned, swept over Niagara Falls | 1903 | |
| 28 | Catcher | St. Louis Cardinals | typhoid fever | 1922 | |
| 34 | Outfielder | Boston Braves | typhoid fever | 1907 | |
| 30 | Third baseman | Chicago Cubs | appendicitis | 1912 | |
| 27 | Pitcher | Chicago White Sox | car crash | 1970 | |
| 25 | Pitcher | Philadelphia Quakers | typhoid fever | 1888 | |
| 24 | Pitcher | Miami Marlins | boat accident | 2016 | |
| 29 | Second baseman | Philadelphia Phillies | duodenal ulcer | 1933 | |
| 27 | Outfielder | Philadelphia Quakers/Philadelphia Athletics | tuberculosis | 1891 | |
| 30 | Pitcher | Milwaukee Brewers | dune buggy crash | 1977 | |
| 23 | Pitcher | Seattle Pilots | homicide, gunshot | 1970 | |
| 24 | Catcher | Baltimore Orioles | plane crash | 1956 | |
| 27 | Outfielder | Washington Senators | killed during World War II serving in United States Army Air Forces | 1944 | |
| 34 | Pitcher | Cincinnati Reds | plane crash | 1925 | |
| 27 | Pitcher | Detroit Tigers | diabetes | 1915 | |
| 24 | Outfielder | Seattle Mariners | homicide, stabbing | 2011 | |
| 29 | Pitcher | St. Louis Cardinals | car crash | 2007 | |
| 29 | Pitcher | Detroit Tigers | heart attack | 1937 | |
| 30 | Catcher | Cincinnati Reds | suicide, cut his own throat | 1940 | |
| 25 | Outfielder | Minnesota Twins | drowned while swimming | 1970 | |
| 27 | Catcher/Outfielder | Brooklyn Atlantics | tuberculosis | 1875 | |
| 22 | Second baseman | Chicago Cubs | plane crash | 1964 | |
| 31 | Pitcher | Cleveland Indians | meningitis | 1911 | |
| 28 | Pitcher | Toronto Blue Jays | hypertensive heart disease | 2007 | |
| 33 | Pitcher | St. Louis Cardinals | heart attack | 2002 | |
| 31 | Outfielder | Brooklyn Dodgers | cerebral hemorrhage sustained during a fight on an airplane | 1935 | |
| 25 | Pitcher | Chicago Colts | tuberculosis | 1899 | |
| 26 | Third baseman | Washington Senators | appendicitis | 1920 | |
| 26 | Catcher | Philadelphia Phillies | car crash | 1929 | |
| 34 | Pitcher | New York Yankees | plane crash | 2006 | |
| 30 | Pitcher | Louisville Colonels | tuberculosis | 1899 | |
| 27 | Infielder | Chicago Cubs | testicular cancer | 1981 | |
| 27 | Outfielder | St. Louis Cardinals | brain tumor | 1922 | |
| 27 | Pitcher | Brooklyn Superbas | tuberculosis, complicated by injuries sustained in a carriage accident | 1901 | |
| 30 | First baseman | Pittsburgh Alleghenys | typhoid fever | 1887 | |
| 28 | Pitcher | Baltimore Orioles | suicide, gunshot | 1894 | |
| 28 | Pitcher | Detroit Tigers | suicide by inhalation of illuminating gas | 1903 | |
| 23 | Shortstop | California Angels | car crash | 1977 | |
| 26 | Catcher | St. Louis Brown Stockings | indeterminate illness | 1876 | |
| 21 | Catcher | Boston Braves | car crash | 1942 | |
| 29 | Pitcher | Pittsburgh Pirates | car crash | 1976 | |
| 32 | Pitcher | Boston Red Sox | homicide, stabbing | 1932 | |
| 32 | Catcher | New York Yankees | plane crash | 1979 | |
| 27 | Outfielder | Pittsburgh Pirates | pneumonia | 1901 | |
| 27 | Pitcher | Cleveland Indians | boat accident | 1993 | |
| 38 | Catcher | Philadelphia Athletics | peritonitis arising from surgery complications following an in-game injury | 1909 | |
| 27 | Outfielder | Washington Senators | Bright's disease | 1909 | |
| 23 | Outfielder | Philadelphia Athletics | drowned while swimming during military training during WWI | 1918 | |
| 34 | Infielder | San Diego Padres | car crash, on his way to join the Padres after being recalled from minor leagues | 1996 | |
| 27 | Pitcher | Los Angeles Angels | accidental drug overdose | 2019 | |
| 27 | Outfielder | Baltimore Orioles | typhoid malaria | 1888 | |
| 34 | Outfielder | Boston Red Sox | suicide by ingestion of carbolic acid | 1907 | |
| 25 | Outfielder | Cincinnati Reds | homicide, gunshot | 2003 | |
| 25 | Infielder | Cincinnati Reds | general streptococcus due to empyema | 1910 | |
| 30 | Catcher | Baltimore Orioles | Bright's disease | 1893 | |
| 22 | Outfielder | St. Louis Cardinals | car crash | 2014 | |
| 26 | Pitcher | Cincinnati Reds | nephritis | 1900 | |
| 22 | Outfielder | Brooklyn Atlantics | drowned while fishing | 1872 | |
| 29 | Shortstop | Texas Rangers | leukemia | 1976 | |
| 33 | Pitcher | Houston Colt.45s | malignant melanoma | 1964 | |
| 25 | Pitcher | Kansas City Royals | car crash | 2017 | |
| 25 | Pitcher | California Angels | inoperable brain tumor | 1965 | |
| 22 | Outfielder | Cleveland Forest Citys | tuberculosis | 1872 | |
| 29 | Pitcher | Houston Astros | carbon monoxide poisoning | 1975 | |
| 29 | Pitcher | Cleveland Indians | car crash | 1993 | |
| 30 | Outfielder | New York Giants | Bright's disease | 1927 | |
Player | Age | Position | Last MLB Season | Last MLB Team | Last Team | Cause of death | Year | Ref |
| 37 | Infielder | 2008 | Houston Astros | Cardenales de Lara | car accident, murdered | 2018 | |
| 31 | Shortstop | 1996 | Houston Astros | Azucareros del Este | car accident | 2000 | |
| 32 | Catcher | 1916 | St. Louis Browns | Little Rock Travelers | injuries sustained serving in the military during WWI | 1918 | |
| 28 | Outfielder | 1917 | Boston Braves | Salt Lake City Bees | influenza, while serving in the U.S. Army Medical Corps during WWI | 1918 | |
| 19 | Pitcher | 1963 | Houston Colt.45s | Salisbury Astros | car crash; the youngest former league player to have died. | 1965 | |
| 29 | Pitcher | 2000 | San Francisco Giants | Seibu Lions | car accident | 2001 | |
| 27 | First baseman | 1985 | Chicago White Sox | Ponce Lions | car accident | 1986 | |
| 37 | Catcher | 1989 | Cincinnati Reds | Caracas Lions | crushed by a falling satellite dish | 1990 | |
| 27 | Third baseman | 1913 | Cincinnati Reds | Mobile Sea Gulls | hit by a pitch in a game | 1916 | |
| 30 | Outfielder | 2002 | Chicago Cubs | Macoto Cobras | congenital disorder | 2005 | |
| 34 | Pitcher | 1954 | Baltimore Orioles | San Antonio Missions | homicide, stabbing | 1955 | |
| 32 | Pitcher | 2004 | Texas Rangers | Tigres de Aragua | car accident | 2011 | |
| 28 | Catcher | 1915 | St. Louis Cardinals | St. Paul Saints | pneumonia, while serving in the U.S. Army Signal Corps during WWI | 1918 | |
| 33 | Pitcher | 2006 | Milwaukee Brewers | Yomiuri Giants | lightning strike | 2008 | |
| 34 | Pitcher | 2015 | Philadelphia Phillies | Free agent | car accident | 2017 | |
| 29 | Pitcher | 2013 | Los Angeles Angels | Sacramento River Cats | organ failure related to cocaine toxicity | 2015 | |
| 40 | Pitcher | 1958 | Chicago White Sox | Indianapolis Indians | heart attack | 1960 | |
| 26 | Pitcher | 1997 | Atlanta Braves | Sioux City Explorers | heart attack and brain aneurysm | 2001 | |
| 37 | Pitcher | 2006 | New York Mets | Aguilas Cibaenas | heart attack | 2010 | |
| 33 | Infielder | 2014 | Arizona Diamondbacks | KT Wiz | car accident | 2017 | |
| 39 | First baseman | 1908 | New York Giants | Milwaukee Brewers | suicide, gunshot | 1910 | |
| 26 | Third baseman | 1995 | St. Louis Cardinals | Brother Elephants | car accident | 1997 | |
| 26 | Third baseman | 1895 | Chicago Colts | Dubuque Westerns | tuberculosis | 1898 | |
| 27 | Outfielder | 1956 | St. Louis Cardinals | Omaha Cardinals | plane crash | 1956 | |
| 22 | Third baseman | 1894 | Pittsburgh Pirates | Washington Little Senators | typhoid fever | 1896 | |
| 29 | Pitcher | 1997 | Toronto Blue Jays | AZL Diamondbacks | car crash | 1999 | |
| 33 | Infielder | 1971 | California Angels | Salt Lake City Angels | car crash | 1972 | |
| 27 | First baseman | 1897 | Louisville Colonels | Norwich Witches | unknown | 1900 | |
| 33 | Infielder | 2018 | Los Angeles Angels | Cardenales de Lara | car accident, murdered | 2018 | |
| 28 | Relief pitcher | 2016 | Chicago White Sox | Free agent | all-terrain vehicle accident | 2017 | |