| Language | Speakers | Status | Comments | Ref |
| Acatepec Mazatec language, Acatepec Mazatec | | Vulnerable | | |
| Akatek language, Akatek | | Vulnerable | | |
| Awakatek language, Awakatek | | Critically endangered | | |
| Ayapanec language, Ayapanec | | Critically endangered | | |
| Ayautla Mazatec language, Ayautla Mazatec | | Vulnerable | | |
| Central Cuicatec language, Central Cuicatec | | Vulnerable | | |
| Central Náhuatl language, Central Náhuatl | | Vulnerable | | |
| Central Otomí language, Central Otomí | | Definitely endangered | | |
| Central Pame language, Central Pame | | Vulnerable | | |
| Central Popoloc language, Central Popoloc | | Severely endangered | | |
| Central Tlapanec language, Central Tlapanec | | Vulnerable | | |
| Central Zoque language, Central Zoque | | Definitely endangered | | |
| Chatino of the western lowlands | | Definitely endangered | | |
| Chatino of Zacatepec language, Chatino of Zacatepec | | Definitely endangered | | |
| Chichimec language, Chichimec | | Vulnerable | | |
| Chihuahua Lower Pima language, Chihuahua Lower Pima | | Definitely endangered | | |
| Chilchotla Mazatec language, Chilchotla Mazatec | | Vulnerable | | |
| Chiquihuitlán Mazatec language, Chiquihuitlán Mazatec | | Definitely endangered | | |
| Chontal Tabasco language, Chontal Tabasco | | Severely endangered | | |
| Chuj language, Chuj | | Critically endangered | | |
| Cocopa language, Cocopa | | Definitely endangered | | |
| Eastern Chocho language, Eastern Chocho | | Severely endangered | | |
| Eastern Cuicatec language, Eastern Cuicatec | | Vulnerable | | |
| Eastern Mazahua language, Eastern Mazahua | | Definitely endangered | | |
| Eastern Popoloc language, Eastern Popoloc | | Vulnerable | | |
| Eastern Tlapanec language, Eastern Tlapanec | | Vulnerable | | |
| Eloxochitlán Mazatec language, Eloxochitlán Mazatec | | Vulnerable | | |
| Filomeno Mata Totonac language, Filomeno Mata Totonac | | Vulnerable | | |
| Higher Reservoir Mazatec language, Higher Reservoir Mazatec | | Vulnerable | | |
| Highland Chontal language, Highland Chontal | | Severely endangered | | |
| Highland Mazatec language, Highland Mazatec | | Vulnerable | | |
| Huasteca Náhuatl language, Huasteca Náhuatl | | Vulnerable | | |
| Huehuetla Tepehua language, Huehuetla Tepehua | | Definitely endangered | | |
| Huehuetlán Mazatec language, Huehuetlán Mazatec | | Vulnerable | | |
| Huichol language, Huichol | | Vulnerable | | |
| Isthmus Náhuatl language, Isthmus Náhuatl | | Vulnerable | | |
| Ixcatec language, Ixcatec | | Critically endangered | | |
| Ixcatlán Mazatec language, Ixcatlán Mazatec | | Vulnerable | | |
| Ixil language, Ixil | | Critically endangered | | |
| Ixtenco Otomí language, Ixtenco Otomí | | Severely endangered | | |
| Jakaltek language, Jakaltek | | Severely endangered | | |
| K'iche' language, K'iche' | | Definitely endangered | | |
| Kaqchikel language, Kaqchikel | | Critically endangered | | |
| Kickapoo language, Kickapoo | | Critically endangered | | |
| Kiliwa language, Kiliwa | | Critically endangered | | |
| Lacandón language, Lacandón | | Critically endangered | | |
| Lower Mixe language, Lower Mixe | | Vulnerable | | |
| Lower Northwestern Otomí language, Lower Northwestern Otomí | | Vulnerable | | |
| Lowland Chontal language, Lowland Chontal | | Critically endangered | | |
| Lowland Mazatec language, Lowland Mazatec | | Vulnerable | | |
| Malinaltepec Tlapanec language, Malinaltepec Tlapanec | | Vulnerable | | |
| Mam language, Mam | | Severely endangered | | |
| Matlatzinca language, Matlatzinca | | Definitely endangered | | |
| Mayo language, Mayo | | Critically endangered | | |
| Mazatlán Mazatec language, Mazatlán Mazatec | | Vulnerable | | |
| Mezquital Otomí language, Mezquital Otomí | | Definitely endangered | | |
| Misantla Totonac language, Misantla Totonac | | Critically endangered | | |
| Mixtec of San Miguel Piedras language, Mixtec of San Miguel Piedras | | Severely endangered | | |
| Mixtec of San Pedro Tidaá language, Mixtec of San Pedro Tidaá | | Severely endangered | | |
| Mixtec of Santa Cruz Itundujia language, Mixtec of Santa Cruz Itundujia | | Definitely endangered | | |
| Mixtec of Santa Inés de Zaragoza language, Mixtec of Santa Inés de Zaragoza | | Definitely endangered | | |
| Mixtec of the central Ravine | | Definitely endangered | | |
| Mixtec of the northeast lowlands | | Severely endangered | | |
Mixtec of the Puebla-Oaxaca border
| | Definitely endangered | | |
| Mixtec of the southwest of Puebla | | Definitely endangered | | |
| Mixtec of Tlaltempan language, Mixtec of Tlaltempan | | Definitely endangered | | |
| Mixtec of Villa de Tututepec language, Mixtec of Villa de Tututepec | | Definitely endangered | | |
| Mixtec of Zapotitlán language, Mixtec of Zapotitlán | | Severely endangered | | |
| Motocintlec language, Motocintlec | | Critically endangered | | |
| Mountain Guarijío language, Mountain Guarijío | | Vulnerable | | |
| Northern Cuicatec language, Northern Cuicatec | | Vulnerable | | |
| Northern Pame language, Northern Pame | | Definitely endangered | | |
| Northern Popoloc language, Northern Popoloc | | Vulnerable | | |
| Northern Tepehuán language, Northern Tepehuán | | Definitely endangered | | |
| Northern Tlapanec language, Northern Tlapanec | | Vulnerable | | |
| Northern Totonac language, Northern Totonac | | Critically endangered | | |
| Northwestern Otomí language, Northwestern Otomí | | Vulnerable | | |
| Northwestern Tarahumara language, Northwestern Tarahumara | | Vulnerable | | |
| Northwestern Tlapanec language, Northwestern Tlapanec | | Vulnerable | | |
| O'odham language, O'odham | | Definitely endangered | | |
| Ocopetatillo Mazatec language, Ocopetatillo Mazatec | | Vulnerable | | |
| Ocoyoacac Otomí language, Ocoyoacac Otomí | | Severely endangered | | |
| Olultecan language, Olultecan | | Severely endangered | | |
| Ozumatlán Totonac language, Ozomatlán Totonac | | Critically endangered | | |
| Paipai language, Paipai | | Severely endangered | | |
| Papantla Totonac language, Papantla Totonac | | Definitely endangered | | |
| Patla-Chicontla Totonac language, Patla-Chicontla Totonac | | Severely endangered | | |
| Purépecha language, Purépecha | | Vulnerable | | |
| Pisaflores Tepehua language, Pisaflores Tepehua | | Vulnerable | | |
| Puebla Mazatec language, Puebla Mazatec | | Vulnerable | | |
| River Guarijío language, River Guarijío | | Vulnerable | | |
| San Dionisio del Mar Huave language, San Dionisio del Mar Huave | | Definitely endangered | | |
| San Francisco del Mar Huave language, San Francisco del Mar Huave | | Critically endangered | | |
| San Mateo del Mar Huave language, San Mateo del Mar Huave | | Vulnerable | | |
| Santa María del Mar Huave language, Santa María del Mar Huave | | Severely endangered | | |
| Sayultec language, Sayultec | | Definitely endangered | | |
| Seri language, Seri | | Vulnerable | | |
| Sierra de Puebla Nahuatl language, Sierra de Puebla Náhuatl | | Definitely endangered | | |
| Sierra Otomí language, Sierra Otomí | | Vulnerable | | |
| Sierra Popoluca language, Sierra Popoluca | | Vulnerable | | |
| Sierra Totonac language, Sierra Totonac | | Severely endangered | | |
| Sonora Lower Pima language, Sonora Lower Pima | | Severely endangered | | |
| Southeastern Tarahumara language, Southeastern Tarahumara | | Vulnerable | | |
| Southern Chocho language, Southern Chocho | | Severely endangered | | |
| Southern Tlapanec language, Southern Tlapanec | | Severely endangered | | |
| Southern Zoque language, Southern Zoque | | Definitely endangered | | |
| Southwestern Tepehuan language, Southwestern Tepehuan | | Vulnerable | | |
| Southwestern Tlapanec language, Southwestern Tlapanec | | Vulnerable | | |
| Soyaltepec Mazatec language, Soyaltepec Mazatec | | Vulnerable | | |
| Tabasco Náhuatl language, Tabasco Náhuatl | | Critically endangered | | |
| Tecóatl Mazatec language, Tecóatl Mazatec | | Vulnerable | | |
| Teko language, Teko | | Severely endangered | | |
| Texistepecan language, Texistepecan | | Severely endangered | | |
| Tilapa Otomí language, Tilapa Otomí | | Severely endangered | | |
| Tipai language, Tipai | | Severely endangered | | |
| Tlachichilco Tepehua language, Tlachichilco Tepehua | | Definitely endangered | | |
| Tlahuica language, Tlahuica | | Severely endangered | | |
| Tuzantec language, Tuzantec | | Critically endangered | | |
| Valle Nacional Chinantec language, Valle Nacional Chinantec | | Definitely endangered | | |
| Western Chocho language, Western Chocho | | Severely endangered | | |
| Western Mazahua language, Western Mazahua | | Definitely endangered | | |
| Western Mazatec language, Western Mazatec | | Vulnerable | | |
| Western Náhuatl language, Western Náhuatl | | Severely endangered | | |
| Western Otomí language, Western Otomí | | Severely endangered | | |
| Western Popoloc language, Western Popoloc | | Severely endangered | | |
| Western Tarahumara language, Western Tarahumara | | Vulnerable | | |
| Western Tlapanec language, Western Tlapanec | | Vulnerable | | |
| Western Zoque language, Western Zoque | | Vulnerable | | |
| Yaqui language, Yaqui | | Vulnerable | | |
| Zapotec of Asunción Tlacolulita language, Zapotec of Asunción Tlacolulita | | Critically endangered | | |
| Zapotec of Mixtepe language, Zapotec of Mixtepe | | Critically endangered | | |
| Zapotec of Petapa language, Zapotec of Petapa | | Definitely endangered | | |
| Zapotec of San Antonino el Alto language, Zapotec of San Antonino el Alto | | Definitely endangered | | |
| Zapotec of San Bartolo Yautepec language, Zapotec of San Bartolo Yautepec | | Severely endangered | | |
| Zapotec of San Felipe Tejalapan language, Zapotec of San Felipe Tejalapan | | Critically endangered | | |
| eastern lowlands Zapotec of the Southern mountains | | Definitely endangered | | |
| northeast Zapotec of the Southern mountains | | Definitely endangered | | |
| northwest lowlands Zapotec of the Southern mountains | | Definitely endangered | | |
| north Zapotec of the Valleys | | Severely endangered | | |
| central Zapotec of the Valleys | | Severely endangered | | |
| middle northwest Zapotec of the Valleys | | Definitely endangered | | |
| west Zapotec of the Valleys | | Definitely endangered | | |
| Zapotec of Zimatlán de Álvarez language, Zapotec of Zimatlán de Álvarez | | Definitely endangered | | |
